Giant cell tumor of soft tissue arising in breast

Steve A. May, Michael T. Deavers, Erika Resetkova, Deborah Johnson, Constance T. Albarracin

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Primary giant cell tumor of soft tissue (GCT-ST) arising in breast is exceedingly rare. We report a case of a 60-year-old woman with a primary breast giant cell tumor that appeared histologically identical to giant cell tumor of bone and had a clinically malignant course. The patient presented with a cystic mass of the breast, suspected on imaging to be an organizing hematoma, possibly related to previous injury. Histopathological evaluation revealed a neoplasm composed of mononuclear cells admixed with osteoclast-like giant cells resembling giant cell tumor of bone. Immunohistochemical staining was positive for CD68, smooth muscle actin, and vimentin, but was negative for a panel of epithelial and additional muscle markers. These features were most consistent with GCT-ST, an uncommon neoplasm of low malignant potential. Despite aggressive surgical treatment achieving clear surgical margins, the patient expired with pulmonary metastases within a year of her initial presentation. This case demonstrates the difficulty of predicting clinical behavior of GCT-ST of breast on the basis of histological features and depth of tumor alone. To our knowledge, this is the first case report of a GCT-ST arising in the breast associated with a fatal outcome. The distinction of this entity from other more common primary breast tumors with giant cell morphology is also emphasized.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalAnnals of Diagnostic Pathology
Issue number5
StatePublished - Oct 2007


  • GCT-ST of breast
  • Giant cell tumor of bone
  • Giant cell tumor of soft tissue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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