TY - JOUR
T1 - Giant cell arteritis versus Takayasu's Arteritis
T2 - Two sides of the same coin?
AU - Mortensen, Peter W.
AU - Raviskanthan, Subahari
AU - Chévez-Barrios, Patricia
AU - Lee, Andrew G.
N1 - Publisher Copyright:
© 2022 Saudi Journal of Ophthalmology.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - There are multiple vasculitides which are distinguished based on multiple criteria, including size of affected vessels, distribution of vessels affected, histopathologic differences, genetic factors, and age at presentation. Takayasu's arteritis (TkA) and giant cell arteritis (GCA) are the two main medium to large vessel vasculitides. These vasculitides are associated with different racial predilections, vascular distributions, age groups, diagnostic criteria, and treatments. Nevertheless, the many shared histopathologic features, genetic factors, and overlap in presentation of these two diseases suggest that they may actually be variable presentations of the same disease process, i.e., large vessel vasculitis. This article will review the genetics, histopathology, disease mechanisms, and diagnostic criteria for both TkA and GCA. Overall, despite major advances our understanding of these two diseases, it is still debated whether these two large vessel vasculitides represent two distinct diseases processes or simply variations of the same disease.
AB - There are multiple vasculitides which are distinguished based on multiple criteria, including size of affected vessels, distribution of vessels affected, histopathologic differences, genetic factors, and age at presentation. Takayasu's arteritis (TkA) and giant cell arteritis (GCA) are the two main medium to large vessel vasculitides. These vasculitides are associated with different racial predilections, vascular distributions, age groups, diagnostic criteria, and treatments. Nevertheless, the many shared histopathologic features, genetic factors, and overlap in presentation of these two diseases suggest that they may actually be variable presentations of the same disease process, i.e., large vessel vasculitis. This article will review the genetics, histopathology, disease mechanisms, and diagnostic criteria for both TkA and GCA. Overall, despite major advances our understanding of these two diseases, it is still debated whether these two large vessel vasculitides represent two distinct diseases processes or simply variations of the same disease.
KW - Giant cell arteritis
KW - Takayasu's arteritis
KW - large vessel vasculitis
KW - pulseless disease
KW - temporal arteritis
KW - temporal artery biopsy
UR - http://www.scopus.com/inward/record.url?scp=85129160110&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85129160110&partnerID=8YFLogxK
U2 - 10.4103/SJOPT.SJOP_152_21
DO - 10.4103/SJOPT.SJOP_152_21
M3 - Review article
AN - SCOPUS:85129160110
SN - 1319-4534
VL - 35
SP - 198
EP - 203
JO - Saudi Journal of Ophthalmology
JF - Saudi Journal of Ophthalmology
IS - 3
ER -