Germline variants drive myelodysplastic syndrome in young adults

Simone Feurstein; Jane E. Churpek; Tom Walsh; Sioban Keel; Marja Hakkarainen; Thomas Schroeder; Ulrich Germing; Stefanie Geyh; Michael Heuser; Felicitas Thol; Christian Pohlkamp; Torsten Haferlach; Juehua Gao; Carolyn Owen; Gudrun Goehring; Brigitte Schlegelberger; Divij Verma; Daniela S. Krause; Guimin Gao; Tara Cronin; Suleyman Gulsuner; Ming Lee; Colin C. Pritchard; Hari Prasanna Subramanian; Daniela del Gaudio; Zejuan Li; Soma Das; Outi Kilpivaara; Ulla Wartiovaara-Kautto; Eunice S. Wang; Elizabeth A. Griffiths; Konstanze Döhner; Hartmut Döhner; Mary Claire King; Lucy A. Godley

doi:10.1038/s41375-021-01137-0

Germline variants drive myelodysplastic syndrome in young adults

Simone Feurstein, Jane E. Churpek, Tom Walsh, Sioban Keel, Marja Hakkarainen, Thomas Schroeder, Ulrich Germing, Stefanie Geyh, Michael Heuser, Felicitas Thol, Christian Pohlkamp, Torsten Haferlach, Juehua Gao, Carolyn Owen, Gudrun Goehring, Brigitte Schlegelberger, Divij Verma, Daniela S. Krause, Guimin Gao, Tara CroninSuleyman Gulsuner, Ming Lee, Colin C. Pritchard, Hari Prasanna Subramanian, Daniela del Gaudio, Zejuan Li, Soma Das, Outi Kilpivaara, Ulla Wartiovaara-Kautto, Eunice S. Wang, Elizabeth A. Griffiths, Konstanze Döhner, Hartmut Döhner, Mary Claire King, Lucy A. Godley

Research output: Contribution to journal › Letter › peer-review

31 Scopus citations

Original language	English (US)
Pages (from-to)	2439-2444
Number of pages	6
Journal	Leukemia
Volume	35
Issue number	8
DOIs	https://doi.org/10.1038/s41375-021-01137-0
State	Published - Aug 2021

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1038/s41375-021-01137-0

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Feurstein, S., Churpek, J. E., Walsh, T., Keel, S., Hakkarainen, M., Schroeder, T., Germing, U., Geyh, S., Heuser, M., Thol, F., Pohlkamp, C., Haferlach, T., Gao, J., Owen, C., Goehring, G., Schlegelberger, B., Verma, D., Krause, D. S., Gao, G., ... Godley, L. A. (2021). Germline variants drive myelodysplastic syndrome in young adults. Leukemia, 35(8), 2439-2444. https://doi.org/10.1038/s41375-021-01137-0

Feurstein, S, Churpek, JE, Walsh, T, Keel, S, Hakkarainen, M, Schroeder, T, Germing, U, Geyh, S, Heuser, M, Thol, F, Pohlkamp, C, Haferlach, T, Gao, J, Owen, C, Goehring, G, Schlegelberger, B, Verma, D, Krause, DS, Gao, G, Cronin, T, Gulsuner, S, Lee, M, Pritchard, CC, Subramanian, HP, del Gaudio, D, Li, Z, Das, S, Kilpivaara, O, Wartiovaara-Kautto, U, Wang, ES, Griffiths, EA, Döhner, K, Döhner, H, King, MC & Godley, LA 2021, 'Germline variants drive myelodysplastic syndrome in young adults', Leukemia, vol. 35, no. 8, pp. 2439-2444. https://doi.org/10.1038/s41375-021-01137-0

@article{2cdedd2787534f5e94f269ef07b9367c,

title = "Germline variants drive myelodysplastic syndrome in young adults",

author = "Simone Feurstein and Churpek, {Jane E.} and Tom Walsh and Sioban Keel and Marja Hakkarainen and Thomas Schroeder and Ulrich Germing and Stefanie Geyh and Michael Heuser and Felicitas Thol and Christian Pohlkamp and Torsten Haferlach and Juehua Gao and Carolyn Owen and Gudrun Goehring and Brigitte Schlegelberger and Divij Verma and Krause, {Daniela S.} and Guimin Gao and Tara Cronin and Suleyman Gulsuner and Ming Lee and Pritchard, {Colin C.} and Subramanian, {Hari Prasanna} and {del Gaudio}, Daniela and Zejuan Li and Soma Das and Outi Kilpivaara and Ulla Wartiovaara-Kautto and Wang, {Eunice S.} and Griffiths, {Elizabeth A.} and Konstanze D{\"o}hner and Hartmut D{\"o}hner and King, {Mary Claire} and Godley, {Lucy A.}",

note = "Funding Information: Acknowledgements The authors would like to gratefully acknowledge all of the individuals who participated in this study and their physicians for submitting the clinical samples. We would also like to thank Michelle Le Beau and Ludmila Hill from the Cancer Cytogenetics Laboratory at The University of Chicago for providing viably frozen bone marrow samples. This study was supported by the Cancer Research Foundation and the Taub Foundation (L.A.G.), the intramural {\textquoteleft}Baustein{\textquoteright} program for Junior Scientists of the Medical Faculty of Ulm University, Ulm, Germany (S.F.), and the German Bundesministerium f{\"u}r Bildung und Forschung {\textquoteleft}MyPred{\textquoteright} (01GM1911B) (B.S., G.G.) and {\textquoteleft}ADDRess{\textquoteright} (01GM1909A) (G.G.) and the Cancer Society of Finland, the Children{\textquoteright}s Cancer Foundation V{\"a}re, and the Sigrid Juselius Foundation (M.H., O.K., U.W-K.). In addition, the NIH supported this work through: P30CA016056 (use of Roswell Park Comprehensive Cancer Center{\textquoteright}s Hematologic Procurement Shared Resource, E.W.), R03HL145253 (J.E.C.), R35CA197458 and R24DK099808 (M-C.K., T.W., S.G., M.L.). We would also like to acknowledge the input of Linda Lutgen-Dunckley, Brandon Martens, and Joseph Moberg from the Roswell Park Hematologic Procurement Shared Resource (CIC 98-05) for providing samples supported by the Cancer Center Support Grant at Roswell Park (2P30CA016056-42). M-C.K. is an American Cancer Society Professor. Funding Information: Conflict of interest We declare the following conflicts of interest: TW consults for Color Genomics. TH is part owner of the Munich Leukemia Laboratory. EAG has received honoraria/advisory board payments from Alexion Pharmaceuticals, Celgene/BMS, AbbVie, and Novartis. EAG has also received institutional research funding from Genentech Inc., Appelis pharmaceuticals, Celldex Therapeutics, and Celgene/BMS. CO has received honoraria/advisory board payments from AbbVie, AstraZeneca, Janssen, Roche, and Novartis. LAG and JEC have received honoraria from UptoDate, Inc. LAG has received advisory board payments from Invitae, Inc.",

year = "2021",

month = aug,

doi = "10.1038/s41375-021-01137-0",

language = "English (US)",

volume = "35",

pages = "2439--2444",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "8",

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TY - JOUR

T1 - Germline variants drive myelodysplastic syndrome in young adults

AU - Feurstein, Simone

AU - Churpek, Jane E.

AU - Walsh, Tom

AU - Keel, Sioban

AU - Hakkarainen, Marja

AU - Schroeder, Thomas

AU - Germing, Ulrich

AU - Geyh, Stefanie

AU - Heuser, Michael

AU - Thol, Felicitas

AU - Pohlkamp, Christian

AU - Haferlach, Torsten

AU - Gao, Juehua

AU - Owen, Carolyn

AU - Goehring, Gudrun

AU - Schlegelberger, Brigitte

AU - Verma, Divij

AU - Krause, Daniela S.

AU - Gao, Guimin

AU - Cronin, Tara

AU - Gulsuner, Suleyman

AU - Lee, Ming

AU - Pritchard, Colin C.

AU - Subramanian, Hari Prasanna

AU - del Gaudio, Daniela

AU - Li, Zejuan

AU - Das, Soma

AU - Kilpivaara, Outi

AU - Wartiovaara-Kautto, Ulla

AU - Wang, Eunice S.

AU - Griffiths, Elizabeth A.

AU - Döhner, Konstanze

AU - Döhner, Hartmut

AU - King, Mary Claire

AU - Godley, Lucy A.

N1 - Funding Information: Acknowledgements The authors would like to gratefully acknowledge all of the individuals who participated in this study and their physicians for submitting the clinical samples. We would also like to thank Michelle Le Beau and Ludmila Hill from the Cancer Cytogenetics Laboratory at The University of Chicago for providing viably frozen bone marrow samples. This study was supported by the Cancer Research Foundation and the Taub Foundation (L.A.G.), the intramural ‘Baustein’ program for Junior Scientists of the Medical Faculty of Ulm University, Ulm, Germany (S.F.), and the German Bundesministerium für Bildung und Forschung ‘MyPred’ (01GM1911B) (B.S., G.G.) and ‘ADDRess’ (01GM1909A) (G.G.) and the Cancer Society of Finland, the Children’s Cancer Foundation Väre, and the Sigrid Juselius Foundation (M.H., O.K., U.W-K.). In addition, the NIH supported this work through: P30CA016056 (use of Roswell Park Comprehensive Cancer Center’s Hematologic Procurement Shared Resource, E.W.), R03HL145253 (J.E.C.), R35CA197458 and R24DK099808 (M-C.K., T.W., S.G., M.L.). We would also like to acknowledge the input of Linda Lutgen-Dunckley, Brandon Martens, and Joseph Moberg from the Roswell Park Hematologic Procurement Shared Resource (CIC 98-05) for providing samples supported by the Cancer Center Support Grant at Roswell Park (2P30CA016056-42). M-C.K. is an American Cancer Society Professor. Funding Information: Conflict of interest We declare the following conflicts of interest: TW consults for Color Genomics. TH is part owner of the Munich Leukemia Laboratory. EAG has received honoraria/advisory board payments from Alexion Pharmaceuticals, Celgene/BMS, AbbVie, and Novartis. EAG has also received institutional research funding from Genentech Inc., Appelis pharmaceuticals, Celldex Therapeutics, and Celgene/BMS. CO has received honoraria/advisory board payments from AbbVie, AstraZeneca, Janssen, Roche, and Novartis. LAG and JEC have received honoraria from UptoDate, Inc. LAG has received advisory board payments from Invitae, Inc.

PY - 2021/8

Y1 - 2021/8

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UR - http://www.scopus.com/inward/citedby.url?scp=85099916475&partnerID=8YFLogxK

U2 - 10.1038/s41375-021-01137-0

DO - 10.1038/s41375-021-01137-0

M3 - Letter

C2 - 33510405

AN - SCOPUS:85099916475

VL - 35

SP - 2439

EP - 2444

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 8

ER -

Germline variants drive myelodysplastic syndrome in young adults

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