Germ line variants of human N-Methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-Ethenoadenine-induced mutations

Sanjay Adhikari; Mahandranauth A. Chetram; Jordan Woodrick; Partha S. Mitra; Praveen V. Manthena; Pooja Khatkar; Sivanesan Dakshanamurthy; Monica Dixon; Soumendra K. Karmahapatra; Nikhil K. Nuthalapati; Suhani Gupta; Ganga Narasimhan; Raja Mazumder; Christopher A. Loffredo; Aykut Üren; Rabindra Roy

doi:10.1074/jbc.M114.627000

Germ line variants of human N-Methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N₆-Ethenoadenine-induced mutations

Sanjay Adhikari, Mahandranauth A. Chetram, Jordan Woodrick, Partha S. Mitra, Praveen V. Manthena, Pooja Khatkar, Sivanesan Dakshanamurthy, Monica Dixon, Soumendra K. Karmahapatra, Nikhil K. Nuthalapati, Suhani Gupta, Ganga Narasimhan, Raja Mazumder, Christopher A. Loffredo, Aykut Üren, Rabindra Roy

Dr. Mary and Ron Neal Cancer Center

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: hMPG initiates repair of mutagenic and tumorigenic modified purine bases.

Original language	English (US)
Pages (from-to)	4966-4980
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	290
Issue number	8
DOIs	https://doi.org/10.1074/jbc.M114.627000
State	Published - Feb 20 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Adhikari, S., Chetram, M. A., Woodrick, J., Mitra, P. S., Manthena, P. V., Khatkar, P., Dakshanamurthy, S., Dixon, M., Karmahapatra, S. K., Nuthalapati, N. K., Gupta, S., Narasimhan, G., Mazumder, R., Loffredo, C. A., Üren, A., & Roy, R. (2015). Germ line variants of human N-Methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N₆-Ethenoadenine-induced mutations. Journal of Biological Chemistry, 290(8), 4966-4980. https://doi.org/10.1074/jbc.M114.627000

Adhikari, S, Chetram, MA, Woodrick, J, Mitra, PS, Manthena, PV, Khatkar, P, Dakshanamurthy, S, Dixon, M, Karmahapatra, SK, Nuthalapati, NK, Gupta, S, Narasimhan, G, Mazumder, R, Loffredo, CA, Üren, A & Roy, R 2015, 'Germ line variants of human N-Methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N₆-Ethenoadenine-induced mutations', Journal of Biological Chemistry, vol. 290, no. 8, pp. 4966-4980. https://doi.org/10.1074/jbc.M114.627000

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title = "Germ line variants of human N-Methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-Ethenoadenine-induced mutations",

abstract = "Background: hMPG initiates repair of mutagenic and tumorigenic modified purine bases.",

author = "Sanjay Adhikari and Chetram, \{Mahandranauth A.\} and Jordan Woodrick and Mitra, \{Partha S.\} and Manthena, \{Praveen V.\} and Pooja Khatkar and Sivanesan Dakshanamurthy and Monica Dixon and Karmahapatra, \{Soumendra K.\} and Nuthalapati, \{Nikhil K.\} and Suhani Gupta and Ganga Narasimhan and Raja Mazumder and Loffredo, \{Christopher A.\} and Aykut {\"U}ren and Rabindra Roy",

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doi = "10.1074/jbc.M114.627000",

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AU - Adhikari, Sanjay

AU - Chetram, Mahandranauth A.

AU - Woodrick, Jordan

AU - Mitra, Partha S.

AU - Manthena, Praveen V.

AU - Khatkar, Pooja

AU - Dakshanamurthy, Sivanesan

AU - Dixon, Monica

AU - Karmahapatra, Soumendra K.

AU - Nuthalapati, Nikhil K.

AU - Gupta, Suhani

AU - Narasimhan, Ganga

AU - Mazumder, Raja

AU - Loffredo, Christopher A.

AU - Üren, Aykut

AU - Roy, Rabindra

PY - 2015/2/20

Y1 - 2015/2/20

N2 - Background: hMPG initiates repair of mutagenic and tumorigenic modified purine bases.

AB - Background: hMPG initiates repair of mutagenic and tumorigenic modified purine bases.

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JO - Journal of Biological Chemistry

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IS - 8

ER -

Germ line variants of human N-Methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N₆-Ethenoadenine-induced mutations

Abstract

ASJC Scopus subject areas

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