Germ line variants of human N-Methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6-Ethenoadenine-induced mutations

Sanjay Adhikari, Mahandranauth A. Chetram, Jordan Woodrick, Partha S. Mitra, Praveen V. Manthena, Pooja Khatkar, Sivanesan Dakshanamurthy, Monica Dixon, Soumendra K. Karmahapatra, Nikhil K. Nuthalapati, Suhani Gupta, Ganga Narasimhan, Raja Mazumder, Christopher A. Loffredo, Aykut Üren, Rabindra Roy

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: hMPG initiates repair of mutagenic and tumorigenic modified purine bases.

Original languageEnglish (US)
Pages (from-to)4966-4980
Number of pages15
JournalJournal of Biological Chemistry
Volume290
Issue number8
DOIs
StatePublished - Feb 20 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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