Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer

Ayrat Gizzatov, Cinzia Stigliano, Jeyerama S. Ananta, Richa Sethi, Rong Xu, Adem Guven, Maricela Ramirez, Haifa Shen, Anil Sood, Mauro Ferrari, Lon J. Wilson, Xuewu Liu, Paolo Decuzzi

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Porous silicon has been used for the delivery of therapeutic and imaging agents in several biomedical applications. Here, mesoporous silicon nanoconstructs (SiMPs) with a discoidal shape and a sub-micrometer size (1000×400nm) have been conjugated with gadolinium-tetraazacyclododecane tetraacetic acid Gd(DOTA) molecules and proposed as contrast agents for Magnetic Resonance Imaging. The surface of the SiMPs with different porosities - small pore (SP: ~5nm) and huge pore (HP: ~40nm) - and of bulk, non-porous silica beads (1000nm in diameter) have been modified with covalently attached (3-aminopropyl)triethoxysilane (APTES) groups, conjugated with DOTA molecules, and reacted with an aqueous solution of GdCl3. The resulting Gd(DOTA) molecules confined within the small pores of the Gd-SiMPs achieve longitudinal relaxivities r1 of ~17 (mMs)-1, which is 4 times greater than for free Gd(DOTA). This enhancement is ascribed to the confinement and stable chelation of Gd(DOTA) molecules within the SiMP mesoporous matrix. The resulting nanoconstructs possess no cytotoxicity and accumulate in ovarian tumors up to 2% of the injected dose per gram tissue, upon tail vein injection. All together this data suggests that Gd-SiMPs could be efficiently used for MR vascular imaging in cancer and other diseases.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalCancer Letters
Volume352
Issue number1
DOIs
StatePublished - Sep 28 2014

Keywords

  • Magnetic Resonance Imaging
  • Mesoporous silicon
  • Nanoconstructs
  • Relaxivity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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