Genomics and proteomics approaches in understanding tumor angiogenesis

Vivek Mittal, Daniel J. Nolan

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Functional genomic and proteomic approaches have begun to revolutionize cancer research. The advent of powerful technologies, such as DNA microarrays, serial analysis of gene expression, RNA interference and proteomics, has accelerated investigations of gene identification and function at a scale never before accomplished. Approaches integrating these technologies with high-throughput forward and reverse genetic screens, are already providing insights into the mechanistic understanding of angiogenesis, leading to the identification of proteins that can be used for selective targeting of tumor vessels.

Original languageEnglish (US)
Pages (from-to)133-147
Number of pages15
JournalExpert Review of Molecular Diagnostics
Volume7
Issue number2
DOIs
StatePublished - Mar 1 2007

Keywords

  • Angiogenesis
  • Cancer
  • DNA microarray
  • Endothelial cell
  • Endothelial progenitor cell
  • Genetic screen
  • In silico
  • Micro-RNA
  • Proteomics
  • RNA interference
  • SAGE

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Genomics and proteomics approaches in understanding tumor angiogenesis'. Together they form a unique fingerprint.

Cite this