Genomic structure and mapping of precerebellin and a precerebellin-related gene

Balaji Kavety; Nancy A. Jenkins; Colin F. Fletcher; Neal G. Copeland; James I. Morgan

doi:10.1016/0169-328X(94)90196-1

Genomic structure and mapping of precerebellin and a precerebellin-related gene

Balaji Kavety, Nancy A. Jenkins, Colin F. Fletcher, Neal G. Copeland, James I. Morgan

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The cerebellum-specific hexadecapeptide, cerebellin, is derived from a larger precursor, precerebellin, that has sequence homology to the complement component C1qB. We report the cloning of the murine homolog of precerebellin, Cbln1, and a closely related gene, Cbln2. Amino acid comparison of Cbln1 with Cbln2 revealed that Cbln2 is 88% identical to the carboxy terminal region of Cbln1. That these are independent genes was confirmed by Southern analysis and genomic mapping. Cbln1 was positioned to the central region of mouse chromosome 8, 2.3 cM distal of JunB and 6.0 cM proximal of Mt1, while Cbln2 mapped to the distal end of mouse chromosome 18, 1.7 cM telomeric of Mbp.

Original language	English (US)
Pages (from-to)	152-156
Number of pages	5
Journal	Molecular Brain Research
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/0169-328X(94)90196-1
State	Published - Nov 1994

Keywords

Cerebellin
Cerebellum
Chromosomal location
Gene structure
Neurological mutant

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Molecular Biology

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10.1016/0169-328X(94)90196-1

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title = "Genomic structure and mapping of precerebellin and a precerebellin-related gene",

abstract = "The cerebellum-specific hexadecapeptide, cerebellin, is derived from a larger precursor, precerebellin, that has sequence homology to the complement component C1qB. We report the cloning of the murine homolog of precerebellin, Cbln1, and a closely related gene, Cbln2. Amino acid comparison of Cbln1 with Cbln2 revealed that Cbln2 is 88% identical to the carboxy terminal region of Cbln1. That these are independent genes was confirmed by Southern analysis and genomic mapping. Cbln1 was positioned to the central region of mouse chromosome 8, 2.3 cM distal of JunB and 6.0 cM proximal of Mt1, while Cbln2 mapped to the distal end of mouse chromosome 18, 1.7 cM telomeric of Mbp.",

keywords = "Cerebellin, Cerebellum, Chromosomal location, Gene structure, Neurological mutant",

author = "Balaji Kavety and Jenkins, {Nancy A.} and Fletcher, {Colin F.} and Copeland, {Neal G.} and Morgan, {James I.}",

note = "Funding Information: We thank D.J. Gilbert for excellent technical assistance. This research was supported, in part, by the National Cancer Institute, DHHS, under contract N01-C0-74101 with ABL. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1994",

month = nov,

doi = "10.1016/0169-328X(94)90196-1",

language = "English (US)",

volume = "27",

pages = "152--156",

journal = "Molecular Brain Research",

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AU - Kavety, Balaji

AU - Jenkins, Nancy A.

AU - Fletcher, Colin F.

AU - Copeland, Neal G.

AU - Morgan, James I.

N1 - Funding Information: We thank D.J. Gilbert for excellent technical assistance. This research was supported, in part, by the National Cancer Institute, DHHS, under contract N01-C0-74101 with ABL. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1994/11

Y1 - 1994/11

N2 - The cerebellum-specific hexadecapeptide, cerebellin, is derived from a larger precursor, precerebellin, that has sequence homology to the complement component C1qB. We report the cloning of the murine homolog of precerebellin, Cbln1, and a closely related gene, Cbln2. Amino acid comparison of Cbln1 with Cbln2 revealed that Cbln2 is 88% identical to the carboxy terminal region of Cbln1. That these are independent genes was confirmed by Southern analysis and genomic mapping. Cbln1 was positioned to the central region of mouse chromosome 8, 2.3 cM distal of JunB and 6.0 cM proximal of Mt1, while Cbln2 mapped to the distal end of mouse chromosome 18, 1.7 cM telomeric of Mbp.

AB - The cerebellum-specific hexadecapeptide, cerebellin, is derived from a larger precursor, precerebellin, that has sequence homology to the complement component C1qB. We report the cloning of the murine homolog of precerebellin, Cbln1, and a closely related gene, Cbln2. Amino acid comparison of Cbln1 with Cbln2 revealed that Cbln2 is 88% identical to the carboxy terminal region of Cbln1. That these are independent genes was confirmed by Southern analysis and genomic mapping. Cbln1 was positioned to the central region of mouse chromosome 8, 2.3 cM distal of JunB and 6.0 cM proximal of Mt1, while Cbln2 mapped to the distal end of mouse chromosome 18, 1.7 cM telomeric of Mbp.

KW - Cerebellin

KW - Cerebellum

KW - Chromosomal location

KW - Gene structure

KW - Neurological mutant

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JF - Molecular Brain Research

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Genomic structure and mapping of precerebellin and a precerebellin-related gene

Abstract

Keywords

ASJC Scopus subject areas

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