Genomic structure and chromosomal localization of the mouse LIM domain- binding protein 1 gene, Ldb1

Tsuyoshi Yamashita; Alan D. Agulnick; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Heiner Westphal

doi:10.1006/geno.1997.5163

Genomic structure and chromosomal localization of the mouse LIM domain- binding protein 1 gene, Ldb1

Tsuyoshi Yamashita, Alan D. Agulnick, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Heiner Westphal

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The LIM domain is a structural motif that is well conserved throughout evolution in a variety of factors known to play important roles in development and cell regulation. Ldb genes encode LIM domain-binding (Ldb) factors. Here we report on the structural organization and chromosomal localization of the mouse Ldb1 gene. It contains at least 10 exons and spans approximately 4 kb of genomic DNA. The transcription initiation site is located 462 bp upstream of the translation initiation codon ATG as determined by 5'-RACE. Sequencing analysis of the 5'-flanking region shows TATA and CCAAT motifs as well as potential binding sites for GATA, CF-1, PEA3, HRE, APRRE, RARE, Myc, and c-Jun. Ldb1 maps to the distal region of mouse chromosome 19 that is syntenic with human chromosome 10q.

Original language	English (US)
Pages (from-to)	87-92
Number of pages	6
Journal	Genomics
Volume	48
Issue number	1
DOIs	https://doi.org/10.1006/geno.1997.5163
State	Published - Feb 15 1998

ASJC Scopus subject areas

Genetics

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title = "Genomic structure and chromosomal localization of the mouse LIM domain- binding protein 1 gene, Ldb1",

abstract = "The LIM domain is a structural motif that is well conserved throughout evolution in a variety of factors known to play important roles in development and cell regulation. Ldb genes encode LIM domain-binding (Ldb) factors. Here we report on the structural organization and chromosomal localization of the mouse Ldb1 gene. It contains at least 10 exons and spans approximately 4 kb of genomic DNA. The transcription initiation site is located 462 bp upstream of the translation initiation codon ATG as determined by 5'-RACE. Sequencing analysis of the 5'-flanking region shows TATA and CCAAT motifs as well as potential binding sites for GATA, CF-1, PEA3, HRE, APRRE, RARE, Myc, and c-Jun. Ldb1 maps to the distal region of mouse chromosome 19 that is syntenic with human chromosome 10q.",

author = "Tsuyoshi Yamashita and Agulnick, \{Alan D.\} and Copeland, \{Neal G.\} and Gilbert, \{Debra J.\} and Jenkins, \{Nancy A.\} and Heiner Westphal",

note = "Funding Information: We thank Mary Bamstead for excellent technical assistance. This research was supported, in part, by the National Cancer Institute, DHHS, under contract with ABL.",

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T1 - Genomic structure and chromosomal localization of the mouse LIM domain- binding protein 1 gene, Ldb1

AU - Yamashita, Tsuyoshi

AU - Agulnick, Alan D.

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Westphal, Heiner

N1 - Funding Information: We thank Mary Bamstead for excellent technical assistance. This research was supported, in part, by the National Cancer Institute, DHHS, under contract with ABL.

PY - 1998/2/15

Y1 - 1998/2/15

N2 - The LIM domain is a structural motif that is well conserved throughout evolution in a variety of factors known to play important roles in development and cell regulation. Ldb genes encode LIM domain-binding (Ldb) factors. Here we report on the structural organization and chromosomal localization of the mouse Ldb1 gene. It contains at least 10 exons and spans approximately 4 kb of genomic DNA. The transcription initiation site is located 462 bp upstream of the translation initiation codon ATG as determined by 5'-RACE. Sequencing analysis of the 5'-flanking region shows TATA and CCAAT motifs as well as potential binding sites for GATA, CF-1, PEA3, HRE, APRRE, RARE, Myc, and c-Jun. Ldb1 maps to the distal region of mouse chromosome 19 that is syntenic with human chromosome 10q.

AB - The LIM domain is a structural motif that is well conserved throughout evolution in a variety of factors known to play important roles in development and cell regulation. Ldb genes encode LIM domain-binding (Ldb) factors. Here we report on the structural organization and chromosomal localization of the mouse Ldb1 gene. It contains at least 10 exons and spans approximately 4 kb of genomic DNA. The transcription initiation site is located 462 bp upstream of the translation initiation codon ATG as determined by 5'-RACE. Sequencing analysis of the 5'-flanking region shows TATA and CCAAT motifs as well as potential binding sites for GATA, CF-1, PEA3, HRE, APRRE, RARE, Myc, and c-Jun. Ldb1 maps to the distal region of mouse chromosome 19 that is syntenic with human chromosome 10q.

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Genomic structure and chromosomal localization of the mouse LIM domain- binding protein 1 gene, Ldb1

Abstract

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