Genomic structure and chromosomal localization of the mouse LIM domain- binding protein 1 gene, Ldb1

Tsuyoshi Yamashita, Alan D. Agulnick, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Heiner Westphal

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The LIM domain is a structural motif that is well conserved throughout evolution in a variety of factors known to play important roles in development and cell regulation. Ldb genes encode LIM domain-binding (Ldb) factors. Here we report on the structural organization and chromosomal localization of the mouse Ldb1 gene. It contains at least 10 exons and spans approximately 4 kb of genomic DNA. The transcription initiation site is located 462 bp upstream of the translation initiation codon ATG as determined by 5'-RACE. Sequencing analysis of the 5'-flanking region shows TATA and CCAAT motifs as well as potential binding sites for GATA, CF-1, PEA3, HRE, APRRE, RARE, Myc, and c-Jun. Ldb1 maps to the distal region of mouse chromosome 19 that is syntenic with human chromosome 10q.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalGenomics
Volume48
Issue number1
DOIs
StatePublished - Feb 15 1998

ASJC Scopus subject areas

  • Genetics

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