Genomic segmental polymorphisms in inbred mouse strains

Jiangzhen Li; Tao Jiang; Jian Hua Mao; Allan Balmain; Leif E. Peterson; Charles Harris; Pulivarthi H. Rao; Paul Havlak; Richard Gibbs; Wei Wen Cai

doi:10.1038/ng1417

Genomic segmental polymorphisms in inbred mouse strains

Jiangzhen Li, Tao Jiang, Jian Hua Mao, Allan Balmain, Leif E. Peterson, Charles Harris, Pulivarthi H. Rao, Paul Havlak, Richard Gibbs, Wei Wen Cai

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.

Original language	English (US)
Pages (from-to)	952-954
Number of pages	3
Journal	Nature Genetics
Volume	36
Issue number	9
DOIs	https://doi.org/10.1038/ng1417
State	Published - Sep 2004

ASJC Scopus subject areas

Genetics

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10.1038/ng1417

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title = "Genomic segmental polymorphisms in inbred mouse strains",

abstract = "By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.",

author = "Jiangzhen Li and Tao Jiang and Mao, \{Jian Hua\} and Allan Balmain and Peterson, \{Leif E.\} and Charles Harris and Rao, \{Pulivarthi H.\} and Paul Havlak and Richard Gibbs and Cai, \{Wei Wen\}",

note = "Funding Information: We thank A. Bradley for the mouse hybrid ER3.4 embryonic stem cell line and Q. Li for technical support in BAC array preparation. This work was support in part by the US Department of Energy. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

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doi = "10.1038/ng1417",

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T1 - Genomic segmental polymorphisms in inbred mouse strains

AU - Li, Jiangzhen

AU - Jiang, Tao

AU - Mao, Jian Hua

AU - Balmain, Allan

AU - Peterson, Leif E.

AU - Harris, Charles

AU - Rao, Pulivarthi H.

AU - Havlak, Paul

AU - Gibbs, Richard

AU - Cai, Wei Wen

N1 - Funding Information: We thank A. Bradley for the mouse hybrid ER3.4 embryonic stem cell line and Q. Li for technical support in BAC array preparation. This work was support in part by the US Department of Energy. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2004/9

Y1 - 2004/9

N2 - By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.

AB - By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.

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JO - Nature Genetics

JF - Nature Genetics

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ER -

Genomic segmental polymorphisms in inbred mouse strains

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