Genomic segmental polymorphisms in inbred mouse strains

Jiangzhen Li, Tao Jiang, Jian Hua Mao, Allan Balmain, Leif E. Peterson, Charles Harris, Pulivarthi H. Rao, Paul Havlak, Richard Gibbs, Wei Wen Cai

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.

Original languageEnglish (US)
Pages (from-to)952-954
Number of pages3
JournalNature Genetics
Volume36
Issue number9
DOIs
StatePublished - Sep 2004

ASJC Scopus subject areas

  • Genetics

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