Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene

Rulang Jiang, Christine R. Norton, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Thomas Gridley

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The Slug gene encodes a zinc finger protein implicated in the generation and migration of neural crest cells in several vertebrate species. Here we describe the genomic organization and chromosomal localization of the mouse Slug (Slugh) gene. The mouse Slug gene consists of three exons spanning approx. 4 kb. Northern blot analysis of RNA isolated from several tissues of adult mice revealed the presence of a single 2.1 kb transcript. The chromosomal location of mouse Slug was determined by interspecific backcross analysis. The mapping results indicated that Slugh is located in the proximal region of mouse chromosome 16.

Original languageEnglish (US)
Pages (from-to)251-254
Number of pages4
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1443
Issue number1-2
DOIs
StatePublished - Nov 26 1998

Keywords

  • Chromosomal localization
  • Genomic expression
  • Genomic organization
  • Mouse Slug (Slugh) gene

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Structural Biology
  • Biophysics

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