Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene

Rulang Jiang; Christine R. Norton; Neal G. Copeland; Debra J. Gilbert; Nancy A. Jenkins; Thomas Gridley

doi:10.1016/S0167-4781(98)00225-5

Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene

Rulang Jiang, Christine R. Norton, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Thomas Gridley

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The Slug gene encodes a zinc finger protein implicated in the generation and migration of neural crest cells in several vertebrate species. Here we describe the genomic organization and chromosomal localization of the mouse Slug (Slugh) gene. The mouse Slug gene consists of three exons spanning approx. 4 kb. Northern blot analysis of RNA isolated from several tissues of adult mice revealed the presence of a single 2.1 kb transcript. The chromosomal location of mouse Slug was determined by interspecific backcross analysis. The mapping results indicated that Slugh is located in the proximal region of mouse chromosome 16.

Original language	English (US)
Pages (from-to)	251-254
Number of pages	4
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1443
Issue number	1-2
DOIs	https://doi.org/10.1016/S0167-4781(98)00225-5
State	Published - Nov 26 1998

Keywords

Chromosomal localization
Genomic expression
Genomic organization
Mouse Slug (Slugh) gene

ASJC Scopus subject areas

Biochemistry
Genetics
Structural Biology
Biophysics

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10.1016/S0167-4781(98)00225-5

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title = "Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene",

abstract = "The Slug gene encodes a zinc finger protein implicated in the generation and migration of neural crest cells in several vertebrate species. Here we describe the genomic organization and chromosomal localization of the mouse Slug (Slugh) gene. The mouse Slug gene consists of three exons spanning approx. 4 kb. Northern blot analysis of RNA isolated from several tissues of adult mice revealed the presence of a single 2.1 kb transcript. The chromosomal location of mouse Slug was determined by interspecific backcross analysis. The mapping results indicated that Slugh is located in the proximal region of mouse chromosome 16.",

keywords = "Chromosomal localization, Genomic expression, Genomic organization, Mouse Slug (Slugh) gene",

author = "Rulang Jiang and Norton, {Christine R.} and Copeland, {Neal G.} and Gilbert, {Debra J.} and Jenkins, {Nancy A.} and Thomas Gridley",

note = "Funding Information: This work was supported by a grant from the NIH (RO1HD34883) to T.G. and by a grant (CA34196) from the National Cancer Institute to the Jackson Laboratory. R.J. is supported by a NRSA postdoctoral fellowship. Research at Frederick was supported by the National Cancer Institute, DHHS, under contract with ABL. ",

year = "1998",

month = nov,

day = "26",

doi = "10.1016/S0167-4781(98)00225-5",

language = "English (US)",

volume = "1443",

pages = "251--254",

journal = "Biochimica et Biophysica Acta - Gene Structure and Expression",

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publisher = "Elsevier B.V.",

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T1 - Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene

AU - Jiang, Rulang

AU - Norton, Christine R.

AU - Copeland, Neal G.

AU - Gilbert, Debra J.

AU - Jenkins, Nancy A.

AU - Gridley, Thomas

N1 - Funding Information: This work was supported by a grant from the NIH (RO1HD34883) to T.G. and by a grant (CA34196) from the National Cancer Institute to the Jackson Laboratory. R.J. is supported by a NRSA postdoctoral fellowship. Research at Frederick was supported by the National Cancer Institute, DHHS, under contract with ABL.

PY - 1998/11/26

Y1 - 1998/11/26

N2 - The Slug gene encodes a zinc finger protein implicated in the generation and migration of neural crest cells in several vertebrate species. Here we describe the genomic organization and chromosomal localization of the mouse Slug (Slugh) gene. The mouse Slug gene consists of three exons spanning approx. 4 kb. Northern blot analysis of RNA isolated from several tissues of adult mice revealed the presence of a single 2.1 kb transcript. The chromosomal location of mouse Slug was determined by interspecific backcross analysis. The mapping results indicated that Slugh is located in the proximal region of mouse chromosome 16.

AB - The Slug gene encodes a zinc finger protein implicated in the generation and migration of neural crest cells in several vertebrate species. Here we describe the genomic organization and chromosomal localization of the mouse Slug (Slugh) gene. The mouse Slug gene consists of three exons spanning approx. 4 kb. Northern blot analysis of RNA isolated from several tissues of adult mice revealed the presence of a single 2.1 kb transcript. The chromosomal location of mouse Slug was determined by interspecific backcross analysis. The mapping results indicated that Slugh is located in the proximal region of mouse chromosome 16.

KW - Chromosomal localization

KW - Genomic expression

KW - Genomic organization

KW - Mouse Slug (Slugh) gene

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DO - 10.1016/S0167-4781(98)00225-5

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AN - SCOPUS:0032569956

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VL - 1443

SP - 251

EP - 254

JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

IS - 1-2

ER -

Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene

Abstract

Keywords

ASJC Scopus subject areas

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