Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor

Yuji Mishina; Atsushi Suzuki; Debra J. Gilbert; Neal G. Copeland; Nancy A. Jenkins; Naoto Ueno; Richard R. Behringer

doi:10.1006/bbrc.1995.1043

Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor

Yuji Mishina, Atsushi Suzuki, Debra J. Gilbert, Neal G. Copeland, Nancy A. Jenkins, Naoto Ueno, Richard R. Behringer

Research output: Contribution to journal › Article › peer-review

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Abstract

We have characterized the structure of a mouse bone morphogenetic protein (BMP) type I receptor gene that can bind both BMP-2 and BMP-4. The mouse BMP-2/4 receptor gene is encoded by 11 exons and spans approximately 38-kb. Most of the intron/exon boundaries are not conserved compared to the kinase domain of the related, activin type II receptor. In addition, whereas the activin type II receptor gene contains large introns (>40 kb), the largest intron of the BMP-2/4 receptor gene is only 6.4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice.

Original language	English (US)
Pages (from-to)	310-317
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	206
Issue number	1
DOIs	https://doi.org/10.1006/bbrc.1995.1043
State	Published - Jan 5 1995

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1995.1043

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abstract = "We have characterized the structure of a mouse bone morphogenetic protein (BMP) type I receptor gene that can bind both BMP-2 and BMP-4. The mouse BMP-2/4 receptor gene is encoded by 11 exons and spans approximately 38-kb. Most of the intron/exon boundaries are not conserved compared to the kinase domain of the related, activin type II receptor. In addition, whereas the activin type II receptor gene contains large introns (>40 kb), the largest intron of the BMP-2/4 receptor gene is only 6.4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice.",

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AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Ueno, Naoto

AU - Behringer, Richard R.

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Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor

Abstract

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