Genomic mapping of murine Zp-2 and Zp-3, two oocyte-specific loci encoding zona pellucida proteins

R. Dwayne Lunsford, Nancy A. Jenkins, Christine A. Kozak, Li fang Liang, Collen M. Silan, Neal G. Copeland, Jurrien Dean

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The zona pellucida is a unique, oocyte-specific matrix that coats the surface of all mammalian eggs. Composed of three sulfated glycoproteins in the mouse (ZP1, ZP2, and ZP3), the zona pellucida facilitates early events in fertilization and protects the embryo during preimplantation development. Using DNA isolated from hamster-mouse somatic cell hybrids and from C57BL 6J × Mus spretus interspecific backcross progeny, Zp-2 was located on chromosome 7, 11.3 ± 3.2 cM distal to Tyr, and Zp-3 was located on chromosome 5, 9.2 ± 2.9 cM distal to Gus.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalGenomics
Volume6
Issue number1
DOIs
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Genetics

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