Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse

Tim Wiltshire, Mathew T. Pletcher, Serge Batalov, S. Whitney Barnes, Lisa M. Tarantino, Michael P. Cooke, Hua Wu, Kevin Smylie, Andrey Santrosyan, Neal G. Copeland, Nancy A. Jenkins, Francis Kalush, Richard J. Mural, Richard J. Glynne, Steve A. Kay, Mark D. Adams, Colin F. Fletcher

Research output: Contribution to journalArticle

201 Scopus citations

Abstract

The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits, including disease susceptibility. To gain insight into the genetic and evolutionary factors influencing such biological variation, we have examined the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice. These analyses define blocks of high or low diversity, often extending across tens of megabases that are delineated by abrupt transitions. These observations provide a striking contrast to the haplotype structure of the human genome.

Original languageEnglish (US)
Pages (from-to)3380-3385
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number6
DOIs
StatePublished - Mar 18 2003

ASJC Scopus subject areas

  • General

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