TY - JOUR
T1 - Genome sequence of a serotype M28 strain of group A Streptococcus
T2 - Potential new insights into puerperal sepsis and bacterial disease specificity
AU - Green, Nicole M.
AU - Zhang, Shizhen
AU - Porcella, Stephen F.
AU - Nagiec, Michal J.
AU - Barbian, Kent D.
AU - Beres, Stephen B.
AU - LeFebvre, Ranee B.
AU - Musser, James M.
N1 - Funding Information:
Received 29 October 2004; accepted 26 January 2005; electronically published 29 July 2005. Financial support: National Institute of Allergy and Infectious Diseases (grant UO1-60595 to J.M.M.). a The first 3 authors contributed equally to the work. Reprints or correspondence: Dr. James M. Musser, Center for Human Bacterial Pathogenesis Research, Dept. of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 ([email protected]).
PY - 2005/9/1
Y1 - 2005/9/1
N2 - Puerperal sepsis, a major cause of death of young women in Europe in the 1800s, was due predominantly to the gram-positive pathogen group A Streptococcus. Studies conducted during past decades have shown that serotype M28 strains are the major group A Streptococcus organisms responsible for many of these infections. To begin to increase our understanding of their enrichment in puerperal sepsis, we sequenced the genome of a genetically representative strain. This strain has genes encoding a novel array of prophage virulence factors, cell-surface proteins, and other molecules likely to contribute to host-pathogen interactions. Importantly, genes for 7 inferred extracellular proteins are encoded by a 37.4-kb foreign DNA element that is shared with group B Streptococcus and is present in all serotype M28 strains. Proteins encoded by the 37.4-kb element were expressed extracellularly and in human infections. Acquisition of foreign genes has helped create a disease-specialist clone of this pathogen.
AB - Puerperal sepsis, a major cause of death of young women in Europe in the 1800s, was due predominantly to the gram-positive pathogen group A Streptococcus. Studies conducted during past decades have shown that serotype M28 strains are the major group A Streptococcus organisms responsible for many of these infections. To begin to increase our understanding of their enrichment in puerperal sepsis, we sequenced the genome of a genetically representative strain. This strain has genes encoding a novel array of prophage virulence factors, cell-surface proteins, and other molecules likely to contribute to host-pathogen interactions. Importantly, genes for 7 inferred extracellular proteins are encoded by a 37.4-kb foreign DNA element that is shared with group B Streptococcus and is present in all serotype M28 strains. Proteins encoded by the 37.4-kb element were expressed extracellularly and in human infections. Acquisition of foreign genes has helped create a disease-specialist clone of this pathogen.
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U2 - 10.1086/430618
DO - 10.1086/430618
M3 - Article
C2 - 16088825
AN - SCOPUS:23944510259
SN - 0022-1899
VL - 192
SP - 760
EP - 770
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -