Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in relA and mnaA

Mia Jade Sales; George Sakoulas; Richard Szubin; Bernhard Palsson; Cesar Arias; Kavindra V. Singh; Barbara E. Murray; Jonathan M. Monk

doi:10.1128/MRA.01515-19

Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in relA and mnaA

Mia Jade Sales, George Sakoulas, Richard Szubin, Bernhard Palsson, Cesar Arias, Kavindra V. Singh, Barbara E. Murray, Jonathan M. Monk

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Staphylococcus aureus strain TX0117 is a methicillin-susceptible bacterium with type A beta-lactamase exhibiting a high cefazolin inoculum effect. TX0117 was cured of blaZ, yielding TX0117c with increased antimicrobial peptide resistance. The sequencing and genome assembly of TX0117 elucidate six mutations between TX0117 and TX0117c, including relA truncation and mnA_1 substitution.

Original language	English (US)
Article number	e01515-19
Journal	Microbiology Resource Announcements
Volume	9
Issue number	18
DOIs	https://doi.org/10.1128/MRA.01515-19
State	Published - Apr 30 2020

ASJC Scopus subject areas

Molecular Biology
Immunology and Microbiology (miscellaneous)
Genetics

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Infectious Disease

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10.1128/MRA.01515-19

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Sales, M. J., Sakoulas, G., Szubin, R., Palsson, B., Arias, C., Singh, K. V., Murray, B. E., & Monk, J. M. (2020). Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in relA and mnaA. Microbiology Resource Announcements, 9(18), Article e01515-19. https://doi.org/10.1128/MRA.01515-19

Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in relA and mnaA. / Sales, Mia Jade; Sakoulas, George; Szubin, Richard et al.
In: Microbiology Resource Announcements, Vol. 9, No. 18, e01515-19, 30.04.2020.

Research output: Contribution to journal › Article › peer-review

Sales, MJ, Sakoulas, G, Szubin, R, Palsson, B, Arias, C , Singh, KV, Murray, BE & Monk, JM 2020, 'Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in relA and mnaA', Microbiology Resource Announcements, vol. 9, no. 18, e01515-19. https://doi.org/10.1128/MRA.01515-19

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abstract = "Staphylococcus aureus strain TX0117 is a methicillin-susceptible bacterium with type A beta-lactamase exhibiting a high cefazolin inoculum effect. TX0117 was cured of blaZ, yielding TX0117c with increased antimicrobial peptide resistance. The sequencing and genome assembly of TX0117 elucidate six mutations between TX0117 and TX0117c, including relA truncation and mnA\_1 substitution.",

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AU - Sakoulas, George

AU - Szubin, Richard

AU - Palsson, Bernhard

AU - Arias, Cesar

AU - Singh, Kavindra V.

AU - Murray, Barbara E.

AU - Monk, Jonathan M.

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Genome Sequence Comparison of Staphylococcus aureus TX0117 and a Beta-Lactamase-Cured Derivative Shows Increased Cationic Peptide Resistance Accompanying Mutations in relA and mnaA

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