Genome scans for genetic predisposition to alcoholism by use of transmission disequilibrium test analyses

Grier P. Page; Terri M. King; Jill S. Barnholtz; Mariza De Andrade; Leif E. Peterson; Christopher I. Amos

doi:10.1002/gepi.1370170747

Genome scans for genetic predisposition to alcoholism by use of transmission disequilibrium test analyses

Grier P. Page, Terri M. King, Jill S. Barnholtz, Mariza De Andrade, Leif E. Peterson, Christopher I. Amos

Research Institute

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2 Scopus citations

Abstract

We report the results of the analysis of three measures of alcoholism and six associated symptoms using transmission disequilibrium (TDT) analysis on data from the Collaborative Study on the Genetics of Alcoholism data set. Implementation of identity-by-state (IBS) routines for error checking revealed 10 reported full siblings that were rejected as a full sibling to all of their purported full siblings with p < 0.05. TDT analysis revealed two loci with significant transmission disequilibrium (p < 0.001) on chromosomes 1 and 7. Analysis by parental origin found alleles at three loci displaying significant disequilibrium in the transmission of the paternal alleles for at least three of the nine tested traits. These loci are on chromosomes 6, 9, and 13. Analyses of Caucasian families alone and the use of a single affected individual from each family also yielded significant results for the loci on chromosomes 6, 9, and 13.

Original language	English (US)
Pages (from-to)	S277-S281
Journal	Genetic Epidemiology
Volume	17
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1002/gepi.1370170747
State	Published - 1999

Keywords

HTR-2A
Identity-by-state
Linkage
Linkage disequilibrium

ASJC Scopus subject areas

Genetics(clinical)
Epidemiology

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10.1002/gepi.1370170747

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title = "Genome scans for genetic predisposition to alcoholism by use of transmission disequilibrium test analyses",

abstract = "We report the results of the analysis of three measures of alcoholism and six associated symptoms using transmission disequilibrium (TDT) analysis on data from the Collaborative Study on the Genetics of Alcoholism data set. Implementation of identity-by-state (IBS) routines for error checking revealed 10 reported full siblings that were rejected as a full sibling to all of their purported full siblings with p < 0.05. TDT analysis revealed two loci with significant transmission disequilibrium (p < 0.001) on chromosomes 1 and 7. Analysis by parental origin found alleles at three loci displaying significant disequilibrium in the transmission of the paternal alleles for at least three of the nine tested traits. These loci are on chromosomes 6, 9, and 13. Analyses of Caucasian families alone and the use of a single affected individual from each family also yielded significant results for the loci on chromosomes 6, 9, and 13.",

keywords = "HTR-2A, Identity-by-state, Linkage, Linkage disequilibrium",

author = "Page, {Grier P.} and King, {Terri M.} and Barnholtz, {Jill S.} and {De Andrade}, Mariza and Peterson, {Leif E.} and Amos, {Christopher I.}",

year = "1999",

doi = "10.1002/gepi.1370170747",

language = "English (US)",

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T1 - Genome scans for genetic predisposition to alcoholism by use of transmission disequilibrium test analyses

AU - Page, Grier P.

AU - King, Terri M.

AU - Barnholtz, Jill S.

AU - De Andrade, Mariza

AU - Peterson, Leif E.

AU - Amos, Christopher I.

PY - 1999

Y1 - 1999

N2 - We report the results of the analysis of three measures of alcoholism and six associated symptoms using transmission disequilibrium (TDT) analysis on data from the Collaborative Study on the Genetics of Alcoholism data set. Implementation of identity-by-state (IBS) routines for error checking revealed 10 reported full siblings that were rejected as a full sibling to all of their purported full siblings with p < 0.05. TDT analysis revealed two loci with significant transmission disequilibrium (p < 0.001) on chromosomes 1 and 7. Analysis by parental origin found alleles at three loci displaying significant disequilibrium in the transmission of the paternal alleles for at least three of the nine tested traits. These loci are on chromosomes 6, 9, and 13. Analyses of Caucasian families alone and the use of a single affected individual from each family also yielded significant results for the loci on chromosomes 6, 9, and 13.

AB - We report the results of the analysis of three measures of alcoholism and six associated symptoms using transmission disequilibrium (TDT) analysis on data from the Collaborative Study on the Genetics of Alcoholism data set. Implementation of identity-by-state (IBS) routines for error checking revealed 10 reported full siblings that were rejected as a full sibling to all of their purported full siblings with p < 0.05. TDT analysis revealed two loci with significant transmission disequilibrium (p < 0.001) on chromosomes 1 and 7. Analysis by parental origin found alleles at three loci displaying significant disequilibrium in the transmission of the paternal alleles for at least three of the nine tested traits. These loci are on chromosomes 6, 9, and 13. Analyses of Caucasian families alone and the use of a single affected individual from each family also yielded significant results for the loci on chromosomes 6, 9, and 13.

KW - HTR-2A

KW - Identity-by-state

KW - Linkage

KW - Linkage disequilibrium

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Genome scans for genetic predisposition to alcoholism by use of transmission disequilibrium test analyses

Abstract

Keywords

ASJC Scopus subject areas

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