TY - JOUR
T1 - Genetics and molecular biology of Wilms' tumor
AU - Chintagumpala, Murali
PY - 1996/1/1
Y1 - 1996/1/1
N2 - The study of children with Wilms' tumor, aniridia, genitourinary malformations, and mental retardation led to the localization and cloning of the Wilms' tumor-suppressor gene WT1 on chromosome 11p13. Studies involving children with Beckwith-Wiedemann syndrome and Wilms' tumor revealed evidence of a second genetic locus on chromosome 11p15, WT2. A third genetic locus not related to chromosome 11 has been implicated through linkage analyses. Additionally, loss of heterozygosity for 16q appears to be an adverse prognostic factor in the treatment of Wilms' tumor. The above molecular genetic findings in Wilms' tumor are reviewed.
AB - The study of children with Wilms' tumor, aniridia, genitourinary malformations, and mental retardation led to the localization and cloning of the Wilms' tumor-suppressor gene WT1 on chromosome 11p13. Studies involving children with Beckwith-Wiedemann syndrome and Wilms' tumor revealed evidence of a second genetic locus on chromosome 11p15, WT2. A third genetic locus not related to chromosome 11 has been implicated through linkage analyses. Additionally, loss of heterozygosity for 16q appears to be an adverse prognostic factor in the treatment of Wilms' tumor. The above molecular genetic findings in Wilms' tumor are reviewed.
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U2 - 10.1097/00042307-199611000-00008
DO - 10.1097/00042307-199611000-00008
M3 - Short survey
AN - SCOPUS:0029962707
SN - 0963-0643
VL - 6
SP - 327
EP - 330
JO - Current Opinion in Urology
JF - Current Opinion in Urology
IS - 6
ER -