Genetics and molecular biology of Wilms' tumor

Murali Chintagumpala

Research output: Contribution to journalShort surveypeer-review


The study of children with Wilms' tumor, aniridia, genitourinary malformations, and mental retardation led to the localization and cloning of the Wilms' tumor-suppressor gene WT1 on chromosome 11p13. Studies involving children with Beckwith-Wiedemann syndrome and Wilms' tumor revealed evidence of a second genetic locus on chromosome 11p15, WT2. A third genetic locus not related to chromosome 11 has been implicated through linkage analyses. Additionally, loss of heterozygosity for 16q appears to be an adverse prognostic factor in the treatment of Wilms' tumor. The above molecular genetic findings in Wilms' tumor are reviewed.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalCurrent Opinion in Urology
Issue number6
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Urology


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