Genetic variants in inflammation pathway genes and asthma in glioma susceptibility

E. Amirian, Yanhong Liu, Michael E. Scheurer, Randa El-Zein, Mark R. Gilbert, Melissa L. Bondy

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Single nucleotide polymorphisms (SNPs) in inflammation- related genes have previously been shown to alter risks of developing various cancers. However, the effects of such SNPs on glioma risk remain unclear. We used a multistrategic approach to elucidate the relationship between glioma risk, asthma/allergies, and 23 literature-based functional SNPs in 11 inflammation genes. Genotyping was conducted on 373 histologically confirmed adult glioma patients and 365 cancer-free controls from the Harris County Brain Tumor Study. Deviations from the Hardy-Weinberg equilibrium were assessed using the x2-test, and Akaike's information criterion was used to determine the best genetic model for each SNP. Odds ratios (ORs) were calculated both for each SNP individually and for grouped analyses, examining the effects of the numbers of adverse alleles on glioma risk in participants with and without asthma. In the single-locus analysis of the 23 examined SNPs, 1 pro-inflammatory and 2 anti-inflammatory gene SNPs were significantly associated with glioma risk (COX2/PTGS2, rs20417 [OR 5 1.41]; IL10, rs1800896 [OR 5 1.57]; and IL13, rs20541 [OR 5 0.39], respectively). When we examined the joint effects of the risk-conferring alleles of these 3 SNPs, we found a significant trend indicating that the risk increases as the number of adverse alleles increase (P 5 .005). Stratifying by asthma status, we found that this dose-response-like trend of increasing risk is only present among those without asthma/allergies (P < .0001). Our study indicates that polymorphisms in inflammation genes are associated with glioma susceptibility, especially when a history of asthma/allergies is absent.

Original languageEnglish (US)
Pages (from-to)444-452
Number of pages9
Issue number5
StatePublished - May 2010


  • Allergy
  • Asthma
  • Glioma
  • Inflammation

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research


Dive into the research topics of 'Genetic variants in inflammation pathway genes and asthma in glioma susceptibility'. Together they form a unique fingerprint.

Cite this