Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease

J. M. Van der Walt, E. R. Martin, W. K. Scott, F. Zhang, M. A. Nance, R. L. Watts, J. P. Hubble, J. L. Haines, W. C. Koller, K. Lyons, R. Pahwa, M. B. Stern, A. Colcher, B. C. Hiner, J. Jankovic, W. G. Ondo, F. H. Allen, C. G. Goetz, G. W. Small, F. MastagliaA. D. Roses, J. M. Stajich, M. W. Booze, K. Fujiwara, R. A. Gibson, L. T. Middleton, B. L. Scott, M. A. Pericak-Vance, J. M. Vance

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).

Original languageEnglish (US)
Pages (from-to)1189-1191
Number of pages3
Issue number7
StatePublished - Apr 8 2003

ASJC Scopus subject areas

  • Clinical Neurology


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