TY - JOUR
T1 - Genetic polymorphism and their contribution to cancer susceptibility.
AU - Conforti-Froes, N.
AU - el-Zein, R.
AU - Au, W.
PY - 1998
Y1 - 1998
N2 - Since the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the individual variations in responses to exposures to carcinogens. The amount of the ultimate carcinogen produced depends on the action of competing activation and detoxification pathways involving cytochrome P450 and glutathione-S-transferases enzymes.
AB - Since the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the individual variations in responses to exposures to carcinogens. The amount of the ultimate carcinogen produced depends on the action of competing activation and detoxification pathways involving cytochrome P450 and glutathione-S-transferases enzymes.
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U2 - 10.1590/s0102-311x1998000700002
DO - 10.1590/s0102-311x1998000700002
M3 - Review article
C2 - 9819460
AN - SCOPUS:0031987143
SN - 0102-311X
VL - 14 Suppl 3
SP - 7
EP - 13
JO - Cadernos de saúde pública / Ministério da Saúde, Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública
JF - Cadernos de saúde pública / Ministério da Saúde, Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública
ER -