Genetic Modification of T Cells

Chiara Bonini; Malcolm K. Brenner; Helen E. Heslop; Richard A. Morgan

doi:10.1016/j.bbmt.2010.09.019

Genetic Modification of T Cells

Chiara Bonini, Malcolm K. Brenner, Helen E. Heslop, Richard A. Morgan

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

Original language	English (US)
Pages (from-to)	S15-S20
Journal	Biology of Blood and Marrow Transplantation
Volume	17
Issue number	1 SUPPL
DOIs	https://doi.org/10.1016/j.bbmt.2010.09.019
State	Published - Jan 2011

Keywords

Gene transfer
Suicide genes
T lymphocytes

ASJC Scopus subject areas

Transplantation
Hematology

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10.1016/j.bbmt.2010.09.019

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title = "Genetic Modification of T Cells",

abstract = "Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.",

keywords = "Gene transfer, Suicide genes, T lymphocytes",

author = "Chiara Bonini and Brenner, \{Malcolm K.\} and Heslop, \{Helen E.\} and Morgan, \{Richard A.\}",

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AU - Bonini, Chiara

AU - Brenner, Malcolm K.

AU - Heslop, Helen E.

AU - Morgan, Richard A.

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Y1 - 2011/1

N2 - Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

AB - Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

KW - Gene transfer

KW - Suicide genes

KW - T lymphocytes

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M3 - Article

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AN - SCOPUS:78650636797

SN - 1083-8791

VL - 17

SP - S15-S20

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

IS - 1 SUPPL

ER -

Genetic Modification of T Cells

Abstract

Keywords

ASJC Scopus subject areas

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