Genetic Modification of T Cells

Chiara Bonini, Malcolm K. Brenner, Helen E. Heslop, Richard A. Morgan

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

Original languageEnglish (US)
Pages (from-to)S15-S20
JournalBiology of Blood and Marrow Transplantation
Volume17
Issue number1 SUPPL
DOIs
StatePublished - Jan 2011

Keywords

  • Gene transfer
  • Suicide genes
  • T lymphocytes

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Fingerprint Dive into the research topics of 'Genetic Modification of T Cells'. Together they form a unique fingerprint.

Cite this