Genetic Modification of T Cells

Chiara Bonini; Malcolm K. Brenner; Helen E. Heslop; Richard A. Morgan

doi:10.1016/j.bbmt.2010.09.019

Genetic Modification of T Cells

Chiara Bonini, Malcolm K. Brenner, Helen E. Heslop, Richard A. Morgan

Research output: Contribution to journal › Article

26 Scopus citations

Abstract

Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

Original language	English (US)
Pages (from-to)	S15-S20
Journal	Biology of Blood and Marrow Transplantation
Volume	17
Issue number	1 SUPPL
DOIs	https://doi.org/10.1016/j.bbmt.2010.09.019
State	Published - Jan 2011

Keywords

Gene transfer
Suicide genes
T lymphocytes

ASJC Scopus subject areas

Transplantation
Hematology

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title = "Genetic Modification of T Cells",

abstract = "Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.",

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