Genetic Modification of T Cells

Chiara Bonini, Malcolm K. Brenner, Helen E. Heslop, Richard A. Morgan

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

Original languageEnglish (US)
Pages (from-to)S15-S20
JournalBiology of Blood and Marrow Transplantation
Issue number1 SUPPL
StatePublished - Jan 2011


  • Gene transfer
  • Suicide genes
  • T lymphocytes

ASJC Scopus subject areas

  • Transplantation
  • Hematology


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