Genetic influence on the relation between exhaled nitric oxide and pulse wave reflection

Research output: Contribution to journalArticle

David Laszlo Tarnoki, Adam Domonkos Tarnoki, Emanuela Medda, Levente Littvay, Zsofia Lazar, Virgilia Toccaceli, Corrado Fagnani, Maria Antonietta Stazi, Lorenza Nisticó, Sonia Brescianini, Luana Penna, Pierleone Lucatelli, Emanuele Boatta, Chiara Zini, Fabrizio Fanelli, Claudio Baracchini, Giorgio Meneghetti, Akos Koller, Janos Osztovits, Gyorgy Jermendy & 10 others Istvan Preda, Robert Gabor Kiss, Kinga Karlinger, Agnes Lannert, Tamas Horvath, Giuseppe Schillaci, Andrea Agnes Molnar, Zsolt Garami, Viktor Berczi, Ildiko Horvath

Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FENO) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared environmental influences to variations and covariation of FENO levels and the marker of elasticity function of arteries. Adult Caucasian twin pairs (n = 117) were recruited in Hungary, Italy and in the United States (83 monozygotic and 34 dizygotic pairs; age: 48 ± 16 SD years). FENO was measured by an electrochemical sensor-based device. Pulse wave reflection (aortic augmentation index, Aixao) was determined by an oscillometric method (Arteriograph). A bivariate Cholesky decomposition model was applied to investigate whether the heritabilities of FENO and Aixao were linked. Genetic effects accounted for 58% (95% confidence interval (CI): 42%, 71%) of the variation in FENO with the remaining 42% (95%CI: 29%, 58%) due to non-shared environmental influences. A modest negative correlation was observed between FENO and Aixao (r = -0.17; 95%CI:-0.32,-0.02). FENO showed a significant negative genetic correlation with Aixao (rg = -0.25; 95%CI:-0.46,-0.02). Thus in humans, variations in FENO are explained both by genetic and non-shared environmental effects. Covariance between FENO and Aixao is explained entirely by shared genetic factors. This is consistent with an overlap among the sets of genes involved in the expression of these phenotypes and provides a basis for further genetic studies on cardiovascular and respiratory diseases.

Original languageEnglish
Article number026008
JournalJournal of Breath Research
Volume7
Issue number2
DOIs
StatePublished - Jun 1 2013

PMID: 23660450

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Genetic influence on the relation between exhaled nitric oxide and pulse wave reflection. / Tarnoki, David Laszlo; Tarnoki, Adam Domonkos; Medda, Emanuela; Littvay, Levente; Lazar, Zsofia; Toccaceli, Virgilia; Fagnani, Corrado; Stazi, Maria Antonietta; Nisticó, Lorenza; Brescianini, Sonia; Penna, Luana; Lucatelli, Pierleone; Boatta, Emanuele; Zini, Chiara; Fanelli, Fabrizio; Baracchini, Claudio; Meneghetti, Giorgio; Koller, Akos; Osztovits, Janos; Jermendy, Gyorgy; Preda, Istvan; Kiss, Robert Gabor; Karlinger, Kinga; Lannert, Agnes; Horvath, Tamas; Schillaci, Giuseppe; Molnar, Andrea Agnes; Garami, Zsolt; Berczi, Viktor; Horvath, Ildiko.

In: Journal of Breath Research, Vol. 7, No. 2, 026008, 01.06.2013.

Research output: Contribution to journalArticle

Harvard

Tarnoki, DL, Tarnoki, AD, Medda, E, Littvay, L, Lazar, Z, Toccaceli, V, Fagnani, C, Stazi, MA, Nisticó, L, Brescianini, S, Penna, L, Lucatelli, P, Boatta, E, Zini, C, Fanelli, F, Baracchini, C, Meneghetti, G, Koller, A, Osztovits, J, Jermendy, G, Preda, I, Kiss, RG, Karlinger, K, Lannert, A, Horvath, T, Schillaci, G, Molnar, AA, Garami, Z, Berczi, V & Horvath, I 2013, 'Genetic influence on the relation between exhaled nitric oxide and pulse wave reflection' Journal of Breath Research, vol. 7, no. 2, 026008. https://doi.org/10.1088/1752-7155/7/2/026008

APA

Tarnoki, D. L., Tarnoki, A. D., Medda, E., Littvay, L., Lazar, Z., Toccaceli, V., ... Horvath, I. (2013). Genetic influence on the relation between exhaled nitric oxide and pulse wave reflection. Journal of Breath Research, 7(2), [026008]. https://doi.org/10.1088/1752-7155/7/2/026008

Vancouver

Tarnoki DL, Tarnoki AD, Medda E, Littvay L, Lazar Z, Toccaceli V et al. Genetic influence on the relation between exhaled nitric oxide and pulse wave reflection. Journal of Breath Research. 2013 Jun 1;7(2). 026008. https://doi.org/10.1088/1752-7155/7/2/026008

Author

Tarnoki, David Laszlo ; Tarnoki, Adam Domonkos ; Medda, Emanuela ; Littvay, Levente ; Lazar, Zsofia ; Toccaceli, Virgilia ; Fagnani, Corrado ; Stazi, Maria Antonietta ; Nisticó, Lorenza ; Brescianini, Sonia ; Penna, Luana ; Lucatelli, Pierleone ; Boatta, Emanuele ; Zini, Chiara ; Fanelli, Fabrizio ; Baracchini, Claudio ; Meneghetti, Giorgio ; Koller, Akos ; Osztovits, Janos ; Jermendy, Gyorgy ; Preda, Istvan ; Kiss, Robert Gabor ; Karlinger, Kinga ; Lannert, Agnes ; Horvath, Tamas ; Schillaci, Giuseppe ; Molnar, Andrea Agnes ; Garami, Zsolt ; Berczi, Viktor ; Horvath, Ildiko. / Genetic influence on the relation between exhaled nitric oxide and pulse wave reflection. In: Journal of Breath Research. 2013 ; Vol. 7, No. 2.

BibTeX

@article{06a4a63254964a0ea96bc5f5907d96b8,
title = "Genetic influence on the relation between exhaled nitric oxide and pulse wave reflection",
abstract = "Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FENO) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared environmental influences to variations and covariation of FENO levels and the marker of elasticity function of arteries. Adult Caucasian twin pairs (n = 117) were recruited in Hungary, Italy and in the United States (83 monozygotic and 34 dizygotic pairs; age: 48 ± 16 SD years). FENO was measured by an electrochemical sensor-based device. Pulse wave reflection (aortic augmentation index, Aixao) was determined by an oscillometric method (Arteriograph). A bivariate Cholesky decomposition model was applied to investigate whether the heritabilities of FENO and Aixao were linked. Genetic effects accounted for 58{\%} (95{\%} confidence interval (CI): 42{\%}, 71{\%}) of the variation in FENO with the remaining 42{\%} (95{\%}CI: 29{\%}, 58{\%}) due to non-shared environmental influences. A modest negative correlation was observed between FENO and Aixao (r = -0.17; 95{\%}CI:-0.32,-0.02). FENO showed a significant negative genetic correlation with Aixao (rg = -0.25; 95{\%}CI:-0.46,-0.02). Thus in humans, variations in FENO are explained both by genetic and non-shared environmental effects. Covariance between FENO and Aixao is explained entirely by shared genetic factors. This is consistent with an overlap among the sets of genes involved in the expression of these phenotypes and provides a basis for further genetic studies on cardiovascular and respiratory diseases.",
author = "Tarnoki, {David Laszlo} and Tarnoki, {Adam Domonkos} and Emanuela Medda and Levente Littvay and Zsofia Lazar and Virgilia Toccaceli and Corrado Fagnani and Stazi, {Maria Antonietta} and Lorenza Nistic{\'o} and Sonia Brescianini and Luana Penna and Pierleone Lucatelli and Emanuele Boatta and Chiara Zini and Fabrizio Fanelli and Claudio Baracchini and Giorgio Meneghetti and Akos Koller and Janos Osztovits and Gyorgy Jermendy and Istvan Preda and Kiss, {Robert Gabor} and Kinga Karlinger and Agnes Lannert and Tamas Horvath and Giuseppe Schillaci and Molnar, {Andrea Agnes} and Zsolt Garami and Viktor Berczi and Ildiko Horvath",
year = "2013",
month = "6",
day = "1",
doi = "10.1088/1752-7155/7/2/026008",
language = "English",
volume = "7",
journal = "Journal of Breath Research",
issn = "1752-7155",
publisher = "IOP Publishing Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Genetic influence on the relation between exhaled nitric oxide and pulse wave reflection

AU - Tarnoki, David Laszlo

AU - Tarnoki, Adam Domonkos

AU - Medda, Emanuela

AU - Littvay, Levente

AU - Lazar, Zsofia

AU - Toccaceli, Virgilia

AU - Fagnani, Corrado

AU - Stazi, Maria Antonietta

AU - Nisticó, Lorenza

AU - Brescianini, Sonia

AU - Penna, Luana

AU - Lucatelli, Pierleone

AU - Boatta, Emanuele

AU - Zini, Chiara

AU - Fanelli, Fabrizio

AU - Baracchini, Claudio

AU - Meneghetti, Giorgio

AU - Koller, Akos

AU - Osztovits, Janos

AU - Jermendy, Gyorgy

AU - Preda, Istvan

AU - Kiss, Robert Gabor

AU - Karlinger, Kinga

AU - Lannert, Agnes

AU - Horvath, Tamas

AU - Schillaci, Giuseppe

AU - Molnar, Andrea Agnes

AU - Garami, Zsolt

AU - Berczi, Viktor

AU - Horvath, Ildiko

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FENO) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared environmental influences to variations and covariation of FENO levels and the marker of elasticity function of arteries. Adult Caucasian twin pairs (n = 117) were recruited in Hungary, Italy and in the United States (83 monozygotic and 34 dizygotic pairs; age: 48 ± 16 SD years). FENO was measured by an electrochemical sensor-based device. Pulse wave reflection (aortic augmentation index, Aixao) was determined by an oscillometric method (Arteriograph). A bivariate Cholesky decomposition model was applied to investigate whether the heritabilities of FENO and Aixao were linked. Genetic effects accounted for 58% (95% confidence interval (CI): 42%, 71%) of the variation in FENO with the remaining 42% (95%CI: 29%, 58%) due to non-shared environmental influences. A modest negative correlation was observed between FENO and Aixao (r = -0.17; 95%CI:-0.32,-0.02). FENO showed a significant negative genetic correlation with Aixao (rg = -0.25; 95%CI:-0.46,-0.02). Thus in humans, variations in FENO are explained both by genetic and non-shared environmental effects. Covariance between FENO and Aixao is explained entirely by shared genetic factors. This is consistent with an overlap among the sets of genes involved in the expression of these phenotypes and provides a basis for further genetic studies on cardiovascular and respiratory diseases.

AB - Nitric oxide has an important role in the development of the structure and function of the airways and vessel walls. Fractional exhaled nitric oxide (FENO) is inversely related to the markers and risk factors of atherosclerosis. We aimed to estimate the relative contribution of genes and shared and non-shared environmental influences to variations and covariation of FENO levels and the marker of elasticity function of arteries. Adult Caucasian twin pairs (n = 117) were recruited in Hungary, Italy and in the United States (83 monozygotic and 34 dizygotic pairs; age: 48 ± 16 SD years). FENO was measured by an electrochemical sensor-based device. Pulse wave reflection (aortic augmentation index, Aixao) was determined by an oscillometric method (Arteriograph). A bivariate Cholesky decomposition model was applied to investigate whether the heritabilities of FENO and Aixao were linked. Genetic effects accounted for 58% (95% confidence interval (CI): 42%, 71%) of the variation in FENO with the remaining 42% (95%CI: 29%, 58%) due to non-shared environmental influences. A modest negative correlation was observed between FENO and Aixao (r = -0.17; 95%CI:-0.32,-0.02). FENO showed a significant negative genetic correlation with Aixao (rg = -0.25; 95%CI:-0.46,-0.02). Thus in humans, variations in FENO are explained both by genetic and non-shared environmental effects. Covariance between FENO and Aixao is explained entirely by shared genetic factors. This is consistent with an overlap among the sets of genes involved in the expression of these phenotypes and provides a basis for further genetic studies on cardiovascular and respiratory diseases.

UR - http://www.scopus.com/inward/record.url?scp=84878797528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878797528&partnerID=8YFLogxK

U2 - 10.1088/1752-7155/7/2/026008

DO - 10.1088/1752-7155/7/2/026008

M3 - Article

VL - 7

JO - Journal of Breath Research

T2 - Journal of Breath Research

JF - Journal of Breath Research

SN - 1752-7155

IS - 2

M1 - 026008

ER -

ID: 3110614