Genetic influence on capillary oxygen saturation: A twin study

Research output: Contribution to journalArticle

David Laszlo Tarnoki, Emanuela Medda, Adam Domonkos Tarnoki, Zsofia Lazar, Corrado Fagnani, Maria Antonietta Stazi, Kinga Karlinger, Peter Torzsa, Laszlo Kalabay, Zsolt Garami, Viktor Berczi, Ildiko Horvath

Background: While heritability has been shown for daytime sleepiness, the heritability of daytime capillary oxygen saturation (SpO2) has not been described in detail. Our aim was to estimate the role of genes and environmental factors-both shared and unshared-in the variation of daytime SpO2. Methods: A total of 193 adult healthy twin pairs (138 monozygotic, 55 dizygotic) were recruited in Hungary and in the United States [age = 43.6 ± 15.6 years (mean ± SD)]. SpO2 was measured by pulse oximetry. Univariate quantitative genetic modeling was performed to decompose the phenotypic variance of the considered parameter into heritability (A), shared (C), and unshared (E) environmental effects. Results: SpO2 twin correlation in monozygotic twins was stronger than in dizygotic twins (0.30 and -0.15, respectively, p < 0.05). Age-, sex-, country-, and body mass index-adjusted genetic effects accounted for 26 % (95 % CI 10, 45 %) of the variance of SpO2, and the unshared environmental component explained the remaining 74 % (95 % CI 59, 89 %). No shared environmental influence on SpO2 was detected. The heritability of SpO2 was not different between smokers and nonsmokers. Conclusion: In summary, individual differences in daytime SpO2 are explained by genetic and unshared environmental effects. The strong unshared environmental influence highlights the role of prevention of known environmental risk factors.

Original languageEnglish
Pages (from-to)429-434
Number of pages6
JournalLung
Volume192
Issue number3
DOIs
StatePublished - Jan 1 2014

PMID: 24584632

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Genetic influence on capillary oxygen saturation : A twin study. / Tarnoki, David Laszlo; Medda, Emanuela; Tarnoki, Adam Domonkos; Lazar, Zsofia; Fagnani, Corrado; Stazi, Maria Antonietta; Karlinger, Kinga; Torzsa, Peter; Kalabay, Laszlo; Garami, Zsolt; Berczi, Viktor; Horvath, Ildiko.

In: Lung, Vol. 192, No. 3, 01.01.2014, p. 429-434.

Research output: Contribution to journalArticle

Harvard

Tarnoki, DL, Medda, E, Tarnoki, AD, Lazar, Z, Fagnani, C, Stazi, MA, Karlinger, K, Torzsa, P, Kalabay, L, Garami, Z, Berczi, V & Horvath, I 2014, 'Genetic influence on capillary oxygen saturation: A twin study' Lung, vol. 192, no. 3, pp. 429-434. https://doi.org/10.1007/s00408-014-9563-z

APA

Tarnoki, D. L., Medda, E., Tarnoki, A. D., Lazar, Z., Fagnani, C., Stazi, M. A., ... Horvath, I. (2014). Genetic influence on capillary oxygen saturation: A twin study. Lung, 192(3), 429-434. https://doi.org/10.1007/s00408-014-9563-z

Vancouver

Tarnoki DL, Medda E, Tarnoki AD, Lazar Z, Fagnani C, Stazi MA et al. Genetic influence on capillary oxygen saturation: A twin study. Lung. 2014 Jan 1;192(3):429-434. https://doi.org/10.1007/s00408-014-9563-z

Author

Tarnoki, David Laszlo ; Medda, Emanuela ; Tarnoki, Adam Domonkos ; Lazar, Zsofia ; Fagnani, Corrado ; Stazi, Maria Antonietta ; Karlinger, Kinga ; Torzsa, Peter ; Kalabay, Laszlo ; Garami, Zsolt ; Berczi, Viktor ; Horvath, Ildiko. / Genetic influence on capillary oxygen saturation : A twin study. In: Lung. 2014 ; Vol. 192, No. 3. pp. 429-434.

BibTeX

@article{0f977918c48743f882d0908c5d3c1ee0,
title = "Genetic influence on capillary oxygen saturation: A twin study",
abstract = "Background: While heritability has been shown for daytime sleepiness, the heritability of daytime capillary oxygen saturation (SpO2) has not been described in detail. Our aim was to estimate the role of genes and environmental factors-both shared and unshared-in the variation of daytime SpO2. Methods: A total of 193 adult healthy twin pairs (138 monozygotic, 55 dizygotic) were recruited in Hungary and in the United States [age = 43.6 ± 15.6 years (mean ± SD)]. SpO2 was measured by pulse oximetry. Univariate quantitative genetic modeling was performed to decompose the phenotypic variance of the considered parameter into heritability (A), shared (C), and unshared (E) environmental effects. Results: SpO2 twin correlation in monozygotic twins was stronger than in dizygotic twins (0.30 and -0.15, respectively, p < 0.05). Age-, sex-, country-, and body mass index-adjusted genetic effects accounted for 26 {\%} (95 {\%} CI 10, 45 {\%}) of the variance of SpO2, and the unshared environmental component explained the remaining 74 {\%} (95 {\%} CI 59, 89 {\%}). No shared environmental influence on SpO2 was detected. The heritability of SpO2 was not different between smokers and nonsmokers. Conclusion: In summary, individual differences in daytime SpO2 are explained by genetic and unshared environmental effects. The strong unshared environmental influence highlights the role of prevention of known environmental risk factors.",
keywords = "Environment, Genetics, Heritability, Oximetry",
author = "Tarnoki, {David Laszlo} and Emanuela Medda and Tarnoki, {Adam Domonkos} and Zsofia Lazar and Corrado Fagnani and Stazi, {Maria Antonietta} and Kinga Karlinger and Peter Torzsa and Laszlo Kalabay and Zsolt Garami and Viktor Berczi and Ildiko Horvath",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s00408-014-9563-z",
language = "English",
volume = "192",
pages = "429--434",
journal = "Lung",
issn = "0341-2040",
publisher = "Springer New York",
number = "3",

}

RIS

TY - JOUR

T1 - Genetic influence on capillary oxygen saturation

T2 - Lung

AU - Tarnoki, David Laszlo

AU - Medda, Emanuela

AU - Tarnoki, Adam Domonkos

AU - Lazar, Zsofia

AU - Fagnani, Corrado

AU - Stazi, Maria Antonietta

AU - Karlinger, Kinga

AU - Torzsa, Peter

AU - Kalabay, Laszlo

AU - Garami, Zsolt

AU - Berczi, Viktor

AU - Horvath, Ildiko

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: While heritability has been shown for daytime sleepiness, the heritability of daytime capillary oxygen saturation (SpO2) has not been described in detail. Our aim was to estimate the role of genes and environmental factors-both shared and unshared-in the variation of daytime SpO2. Methods: A total of 193 adult healthy twin pairs (138 monozygotic, 55 dizygotic) were recruited in Hungary and in the United States [age = 43.6 ± 15.6 years (mean ± SD)]. SpO2 was measured by pulse oximetry. Univariate quantitative genetic modeling was performed to decompose the phenotypic variance of the considered parameter into heritability (A), shared (C), and unshared (E) environmental effects. Results: SpO2 twin correlation in monozygotic twins was stronger than in dizygotic twins (0.30 and -0.15, respectively, p < 0.05). Age-, sex-, country-, and body mass index-adjusted genetic effects accounted for 26 % (95 % CI 10, 45 %) of the variance of SpO2, and the unshared environmental component explained the remaining 74 % (95 % CI 59, 89 %). No shared environmental influence on SpO2 was detected. The heritability of SpO2 was not different between smokers and nonsmokers. Conclusion: In summary, individual differences in daytime SpO2 are explained by genetic and unshared environmental effects. The strong unshared environmental influence highlights the role of prevention of known environmental risk factors.

AB - Background: While heritability has been shown for daytime sleepiness, the heritability of daytime capillary oxygen saturation (SpO2) has not been described in detail. Our aim was to estimate the role of genes and environmental factors-both shared and unshared-in the variation of daytime SpO2. Methods: A total of 193 adult healthy twin pairs (138 monozygotic, 55 dizygotic) were recruited in Hungary and in the United States [age = 43.6 ± 15.6 years (mean ± SD)]. SpO2 was measured by pulse oximetry. Univariate quantitative genetic modeling was performed to decompose the phenotypic variance of the considered parameter into heritability (A), shared (C), and unshared (E) environmental effects. Results: SpO2 twin correlation in monozygotic twins was stronger than in dizygotic twins (0.30 and -0.15, respectively, p < 0.05). Age-, sex-, country-, and body mass index-adjusted genetic effects accounted for 26 % (95 % CI 10, 45 %) of the variance of SpO2, and the unshared environmental component explained the remaining 74 % (95 % CI 59, 89 %). No shared environmental influence on SpO2 was detected. The heritability of SpO2 was not different between smokers and nonsmokers. Conclusion: In summary, individual differences in daytime SpO2 are explained by genetic and unshared environmental effects. The strong unshared environmental influence highlights the role of prevention of known environmental risk factors.

KW - Environment

KW - Genetics

KW - Heritability

KW - Oximetry

UR - http://www.scopus.com/inward/record.url?scp=84901267878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901267878&partnerID=8YFLogxK

U2 - 10.1007/s00408-014-9563-z

DO - 10.1007/s00408-014-9563-z

M3 - Article

VL - 192

SP - 429

EP - 434

JO - Lung

JF - Lung

SN - 0341-2040

IS - 3

ER -

ID: 2939325