Genetic determination in onset age of wrist fracture

Donghai Xiong, Wei Wang, Yuan Chen, Hui Jiang, Hong Wen Deng

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The onset age of fracture may be useful to explore the clinical and genetic heterogeneity of fracture study. In the present study, we investigated the heritability of the onset age of wrist fracture (OAWF) in 30 female full-sib pairs. The phenotypic correlation coefficient of OAWF was 0.309 (P = 0.09) for this cohort of female sib pairs, and the narrow-sense heritability (h 2) was estimated to be 0.618 (P = 0.09). In addition, the h 2 derived from the variance component model implemented in SOLAR was 0.722 (P < 0.05). This study, for the very first time, suggested that OAWF is under genetic control and thus potentially helps clarify genetic heterogeneity of wrist fracture.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalJournal of Human Genetics
Issue number6
StatePublished - Jun 2007


  • Heritability
  • Onset age
  • Wrist fracture

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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