Genetic determination in onset age of wrist fracture

Donghai Xiong; Wei Wang; Yuan Chen; Hui Jiang; Hong Wen Deng

doi:10.1007/s10038-007-0141-6

Genetic determination in onset age of wrist fracture

Donghai Xiong, Wei Wang, Yuan Chen, Hui Jiang, Hong Wen Deng

Academic Institute

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The onset age of fracture may be useful to explore the clinical and genetic heterogeneity of fracture study. In the present study, we investigated the heritability of the onset age of wrist fracture (OAWF) in 30 female full-sib pairs. The phenotypic correlation coefficient of OAWF was 0.309 (P = 0.09) for this cohort of female sib pairs, and the narrow-sense heritability (h ²) was estimated to be 0.618 (P = 0.09). In addition, the h ² derived from the variance component model implemented in SOLAR was 0.722 (P < 0.05). This study, for the very first time, suggested that OAWF is under genetic control and thus potentially helps clarify genetic heterogeneity of wrist fracture.

Original language	English (US)
Pages (from-to)	481-484
Number of pages	4
Journal	Journal of Human Genetics
Volume	52
Issue number	6
DOIs	https://doi.org/10.1007/s10038-007-0141-6
State	Published - Jun 2007

Keywords

Heritability
Onset age
Wrist fracture

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1007/s10038-007-0141-6

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abstract = "The onset age of fracture may be useful to explore the clinical and genetic heterogeneity of fracture study. In the present study, we investigated the heritability of the onset age of wrist fracture (OAWF) in 30 female full-sib pairs. The phenotypic correlation coefficient of OAWF was 0.309 (P = 0.09) for this cohort of female sib pairs, and the narrow-sense heritability (h 2) was estimated to be 0.618 (P = 0.09). In addition, the h 2 derived from the variance component model implemented in SOLAR was 0.722 (P < 0.05). This study, for the very first time, suggested that OAWF is under genetic control and thus potentially helps clarify genetic heterogeneity of wrist fracture.",

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AU - Xiong, Donghai

AU - Wang, Wei

AU - Chen, Yuan

AU - Jiang, Hui

AU - Deng, Hong Wen

PY - 2007/6

Y1 - 2007/6

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AB - The onset age of fracture may be useful to explore the clinical and genetic heterogeneity of fracture study. In the present study, we investigated the heritability of the onset age of wrist fracture (OAWF) in 30 female full-sib pairs. The phenotypic correlation coefficient of OAWF was 0.309 (P = 0.09) for this cohort of female sib pairs, and the narrow-sense heritability (h 2) was estimated to be 0.618 (P = 0.09). In addition, the h 2 derived from the variance component model implemented in SOLAR was 0.722 (P < 0.05). This study, for the very first time, suggested that OAWF is under genetic control and thus potentially helps clarify genetic heterogeneity of wrist fracture.

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Genetic determination in onset age of wrist fracture

Abstract

Keywords

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