Genetic contributions to generalized arousal of brain and behavior

J. Garey; A. Goodwillie; J. Frohlich; M. Morgan; J. A. Gustafsson; O. Smithies; K. S. Korach; S. Ogawa; D. W. Pfaff

doi:10.1073/pnas.1633773100

Genetic contributions to generalized arousal of brain and behavior

J. Garey, A. Goodwillie, J. Frohlich, M. Morgan, J. A. Gustafsson, O. Smithies, K. S. Korach, S. Ogawa, D. W. Pfaff

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-α), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-β, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.

Original language	English (US)
Pages (from-to)	11019-11022
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	100
Issue number	19
DOIs	https://doi.org/10.1073/pnas.1633773100
State	Published - Sep 16 2003

Keywords

Estrogen
Estrogen receptor
Genomics
Mice
Motivation

ASJC Scopus subject areas

Genetics
General

Access to Document

10.1073/pnas.1633773100

Cite this

@article{c97e53136cc746d5b0ee6c30ddd440ae,

title = "Genetic contributions to generalized arousal of brain and behavior",

abstract = "We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-α), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-β, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.",

keywords = "Estrogen, Estrogen receptor, Genomics, Mice, Motivation",

author = "J. Garey and A. Goodwillie and J. Frohlich and M. Morgan and Gustafsson, \{J. A.\} and O. Smithies and Korach, \{K. S.\} and S. Ogawa and Pfaff, \{D. W.\}",

year = "2003",

month = sep,

day = "16",

doi = "10.1073/pnas.1633773100",

language = "English (US)",

volume = "100",

pages = "11019--11022",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "19",

}

TY - JOUR

T1 - Genetic contributions to generalized arousal of brain and behavior

AU - Garey, J.

AU - Goodwillie, A.

AU - Frohlich, J.

AU - Morgan, M.

AU - Gustafsson, J. A.

AU - Smithies, O.

AU - Korach, K. S.

AU - Ogawa, S.

AU - Pfaff, D. W.

PY - 2003/9/16

Y1 - 2003/9/16

N2 - We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-α), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-β, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.

AB - We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-α), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-β, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.

KW - Estrogen

KW - Estrogen receptor

KW - Genomics

KW - Mice

KW - Motivation

UR - https://www.scopus.com/pages/publications/0141479955

UR - https://www.scopus.com/inward/citedby.url?scp=0141479955&partnerID=8YFLogxK

U2 - 10.1073/pnas.1633773100

DO - 10.1073/pnas.1633773100

M3 - Article

C2 - 12930901

AN - SCOPUS:0141479955

SN - 0027-8424

VL - 100

SP - 11019

EP - 11022

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 19

ER -

Genetic contributions to generalized arousal of brain and behavior

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this