Genetic contributions to generalized arousal of brain and behavior

J. Garey; A. Goodwillie; J. Frohlich; M. Morgan; J. A. Gustafsson; O. Smithies; K. S. Korach; S. Ogawa; D. W. Pfaff

doi:10.1073/pnas.1633773100

Genetic contributions to generalized arousal of brain and behavior

J. Garey, A. Goodwillie, J. Frohlich, M. Morgan, J. A. Gustafsson, O. Smithies, K. S. Korach, S. Ogawa, D. W. Pfaff

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87 Scopus citations

Abstract

We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-α), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-β, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.

Original language	English (US)
Pages (from-to)	11019-11022
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	100
Issue number	19
DOIs	https://doi.org/10.1073/pnas.1633773100
State	Published - Sep 16 2003

Keywords

Estrogen
Estrogen receptor
Genomics
Mice
Motivation

ASJC Scopus subject areas

Genetics
General

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10.1073/pnas.1633773100

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AU - Garey, J.

AU - Goodwillie, A.

AU - Frohlich, J.

AU - Morgan, M.

AU - Gustafsson, J. A.

AU - Smithies, O.

AU - Korach, K. S.

AU - Ogawa, S.

AU - Pfaff, D. W.

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Genetic contributions to generalized arousal of brain and behavior

Abstract

Keywords

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