Genetic characterization of a cryptic genospecies of Haemophilus causing urogenital and neonatal infections

R. Quentin, C. Martin, J. M. Musser, N. Pasquier-Picard, A. Goudeau

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

In recent years, reports originating from several areas of the world have identified biotype IV strains of Haemophilus influenzae as a cause of serious urogenital, neonatal, and mother-infant infections. Preliminary analysis of a sample of biotype IV isolates found evidence for a cryptic genospecies of Haemophilus (R. Quentin, A. Goudeau, R. J. Wallace, Jr., A. L. Smith, R. K. Selander, and J. M. Musser. J. Gen. Microbiol. 136:1203-1209, 1990). Eighteen biotype IV strains assigned to the cryptic genospecies were further characterized by their rDNA restriction fragment length polymorphism patterns and genomic DNA-DNA hybridization. Isolates of the cryptic genospecies have distinctive rDNA restriction fragment length polymorphisms that differ from those of Haemophilus haemolyticus and H. influenzae. Genomic hybridization studies show that these organisms are allied with H. influenzae and H. haemolyticus and suggest a distant trifurcation of H. influenzae, H. haemolyticus, and the cryptic genospecies.

Original languageEnglish (US)
Pages (from-to)1111-1116
Number of pages6
JournalJournal of Clinical Microbiology
Volume31
Issue number5
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Microbiology (medical)

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