Genetic and environmental influence on thyroid gland volume and thickness of thyroid isthmus: a twin study

Research output: Contribution to journalArticle

Adam D omonkos Tarnoki, David L aszlo Tarnoki, Gabor Speer, Levente Littvay, Pal Bata, Zsolt Garami, Viktor Berczi, Kinga Karlinger

OBJECTIVES: Decreased thyroid volume has been related to increased prevalence of thyroid cancer.

SUBJECTS AND METHODS: One hundred and fourteen Hungarian adult twin pairs (69 monozygotic, 45 dizygotic) with or without known thyroid disorders underwent thyroid ultrasound. Thickness of the thyroid isthmus was measured at the thickest portion of the gland in the midline using electronic calipers at the time of scanning. Volume of the thyroid lobe was computed according to the following formula: thyroid height*width*depth*correction factor (0.63).

RESULTS: Age-, sex-, body mass index- and smoking-adjusted heritability of the thickness of thyroid isthmus was 50% (95% confidence interval [CI], 35 to 66%). Neither left nor right thyroid volume showed additive genetic effects, but shared environments were 68% (95% CI, 48 to 80%) and 79% (95% CI, 72 to 87%), respectively. Magnitudes of monozygotic and dizygotic co-twin correlations were not substantially impacted by the correction of covariates of body mass index and smoking. Unshared environmental effects showed a moderate influence on dependent parameters (24-50%).

CONCLUSIONS: Our analysis support that familial factors are important for thyroid measures in a general twin population. A larger sample size is needed to show whether this is because of common environmental (e.g. intrauterine effects, regional nutrition habits, iodine supply) or genetic effects.

Original languageEnglish (US)
Pages (from-to)487-494
Number of pages8
JournalArchives of endocrinology and metabolism
Volume59
Issue number6
DOIs
StatePublished - Dec 1 2015

PMID: 26421673

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Genetic and environmental influence on thyroid gland volume and thickness of thyroid isthmus : a twin study. / Tarnoki, Adam D omonkos; Tarnoki, David L aszlo; Speer, Gabor; Littvay, Levente; Bata, Pal; Garami, Zsolt; Berczi, Viktor; Karlinger, Kinga.

In: Archives of endocrinology and metabolism, Vol. 59, No. 6, 01.12.2015, p. 487-494.

Research output: Contribution to journalArticle

Harvard

Tarnoki, ADO, Tarnoki, DLA, Speer, G, Littvay, L, Bata, P, Garami, Z, Berczi, V & Karlinger, K 2015, 'Genetic and environmental influence on thyroid gland volume and thickness of thyroid isthmus: a twin study' Archives of endocrinology and metabolism, vol. 59, no. 6, pp. 487-494. https://doi.org/10.1590/2359-3997000000110

APA

Tarnoki, A. D. O., Tarnoki, D. L. A., Speer, G., Littvay, L., Bata, P., Garami, Z., ... Karlinger, K. (2015). Genetic and environmental influence on thyroid gland volume and thickness of thyroid isthmus: a twin study. Archives of endocrinology and metabolism, 59(6), 487-494. https://doi.org/10.1590/2359-3997000000110

Vancouver

Tarnoki ADO, Tarnoki DLA, Speer G, Littvay L, Bata P, Garami Z et al. Genetic and environmental influence on thyroid gland volume and thickness of thyroid isthmus: a twin study. Archives of endocrinology and metabolism. 2015 Dec 1;59(6):487-494. https://doi.org/10.1590/2359-3997000000110

Author

Tarnoki, Adam D omonkos ; Tarnoki, David L aszlo ; Speer, Gabor ; Littvay, Levente ; Bata, Pal ; Garami, Zsolt ; Berczi, Viktor ; Karlinger, Kinga. / Genetic and environmental influence on thyroid gland volume and thickness of thyroid isthmus : a twin study. In: Archives of endocrinology and metabolism. 2015 ; Vol. 59, No. 6. pp. 487-494.

BibTeX

@article{f2bd88cd75fe4ffb9ef16f62790de6bc,
title = "Genetic and environmental influence on thyroid gland volume and thickness of thyroid isthmus: a twin study",
abstract = "OBJECTIVES: Decreased thyroid volume has been related to increased prevalence of thyroid cancer.SUBJECTS AND METHODS: One hundred and fourteen Hungarian adult twin pairs (69 monozygotic, 45 dizygotic) with or without known thyroid disorders underwent thyroid ultrasound. Thickness of the thyroid isthmus was measured at the thickest portion of the gland in the midline using electronic calipers at the time of scanning. Volume of the thyroid lobe was computed according to the following formula: thyroid height*width*depth*correction factor (0.63).RESULTS: Age-, sex-, body mass index- and smoking-adjusted heritability of the thickness of thyroid isthmus was 50{\%} (95{\%} confidence interval [CI], 35 to 66{\%}). Neither left nor right thyroid volume showed additive genetic effects, but shared environments were 68{\%} (95{\%} CI, 48 to 80{\%}) and 79{\%} (95{\%} CI, 72 to 87{\%}), respectively. Magnitudes of monozygotic and dizygotic co-twin correlations were not substantially impacted by the correction of covariates of body mass index and smoking. Unshared environmental effects showed a moderate influence on dependent parameters (24-50{\%}).CONCLUSIONS: Our analysis support that familial factors are important for thyroid measures in a general twin population. A larger sample size is needed to show whether this is because of common environmental (e.g. intrauterine effects, regional nutrition habits, iodine supply) or genetic effects.",
author = "Tarnoki, {Adam D omonkos} and Tarnoki, {David L aszlo} and Gabor Speer and Levente Littvay and Pal Bata and Zsolt Garami and Viktor Berczi and Kinga Karlinger",
year = "2015",
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language = "English (US)",
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pages = "487--494",
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RIS

TY - JOUR

T1 - Genetic and environmental influence on thyroid gland volume and thickness of thyroid isthmus

T2 - Archives of endocrinology and metabolism

AU - Tarnoki, Adam D omonkos

AU - Tarnoki, David L aszlo

AU - Speer, Gabor

AU - Littvay, Levente

AU - Bata, Pal

AU - Garami, Zsolt

AU - Berczi, Viktor

AU - Karlinger, Kinga

PY - 2015/12/1

Y1 - 2015/12/1

N2 - OBJECTIVES: Decreased thyroid volume has been related to increased prevalence of thyroid cancer.SUBJECTS AND METHODS: One hundred and fourteen Hungarian adult twin pairs (69 monozygotic, 45 dizygotic) with or without known thyroid disorders underwent thyroid ultrasound. Thickness of the thyroid isthmus was measured at the thickest portion of the gland in the midline using electronic calipers at the time of scanning. Volume of the thyroid lobe was computed according to the following formula: thyroid height*width*depth*correction factor (0.63).RESULTS: Age-, sex-, body mass index- and smoking-adjusted heritability of the thickness of thyroid isthmus was 50% (95% confidence interval [CI], 35 to 66%). Neither left nor right thyroid volume showed additive genetic effects, but shared environments were 68% (95% CI, 48 to 80%) and 79% (95% CI, 72 to 87%), respectively. Magnitudes of monozygotic and dizygotic co-twin correlations were not substantially impacted by the correction of covariates of body mass index and smoking. Unshared environmental effects showed a moderate influence on dependent parameters (24-50%).CONCLUSIONS: Our analysis support that familial factors are important for thyroid measures in a general twin population. A larger sample size is needed to show whether this is because of common environmental (e.g. intrauterine effects, regional nutrition habits, iodine supply) or genetic effects.

AB - OBJECTIVES: Decreased thyroid volume has been related to increased prevalence of thyroid cancer.SUBJECTS AND METHODS: One hundred and fourteen Hungarian adult twin pairs (69 monozygotic, 45 dizygotic) with or without known thyroid disorders underwent thyroid ultrasound. Thickness of the thyroid isthmus was measured at the thickest portion of the gland in the midline using electronic calipers at the time of scanning. Volume of the thyroid lobe was computed according to the following formula: thyroid height*width*depth*correction factor (0.63).RESULTS: Age-, sex-, body mass index- and smoking-adjusted heritability of the thickness of thyroid isthmus was 50% (95% confidence interval [CI], 35 to 66%). Neither left nor right thyroid volume showed additive genetic effects, but shared environments were 68% (95% CI, 48 to 80%) and 79% (95% CI, 72 to 87%), respectively. Magnitudes of monozygotic and dizygotic co-twin correlations were not substantially impacted by the correction of covariates of body mass index and smoking. Unshared environmental effects showed a moderate influence on dependent parameters (24-50%).CONCLUSIONS: Our analysis support that familial factors are important for thyroid measures in a general twin population. A larger sample size is needed to show whether this is because of common environmental (e.g. intrauterine effects, regional nutrition habits, iodine supply) or genetic effects.

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DO - 10.1590/2359-3997000000110

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EP - 494

JO - Archives of endocrinology and metabolism

JF - Archives of endocrinology and metabolism

SN - 2359-4292

IS - 6

ER -

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