Genetic and environmental factors on the relation of lung function and arterial stiffness

Research output: Contribution to journalArticle

David Laszlo Tarnoki, Adam Domonkos Tarnoki, Zsofia Lazar, Emanuela Medda, Levente Littvay, Rodolfo Cotichini, Corrado Fagnani, Maria Antonietta Stazi, Lorenza Nisticó, Pierleone Lucatelli, Emanuele Boatta, Chiara Zini, Fabrizio Fanelli, Claudio Baracchini, Giorgio Meneghetti, Gyorgy Jermendy, István Préda, Róbert Gábor Kiss, Kinga Karlinger, Agnes Lannert & 5 others Giuseppe Schillaci, Andrea Agnes Molnar, Zsolt Garami, Viktor Berczi, Ildiko Horvath

Background: An association between reduced lung function and increased cardiovascular risk has been reported, but the underlying mechanisms are unknown. The aim of this study was to assess the heritability of lung function and to estimate its genetic association with arterial stiffness. Methods: 150 monozygotic and 42 dizygotic healthy Hungarian and American Caucasian twin pairs (age 43 ± 17 years) underwent spirometry (forced vital capacity/FVC/, forced expiratory volume in 1 s/FEV1/; MIR Minispir, USA); and their brachial and central augmentation indices (AIx), and aortic pulse wave velocity (PWV) were measured by oscillometric Arteriograph (TensioMed Ltd, Budapest, Hungary). Phenotypic correlations and bivariate Cholesky decomposition models were applied. Results: Age-, sex-, country- and smoking-adjusted heritability of FEV1, percent predicted FEV1, FVC and percent predicted FVC were 73% (95% confidence interval /CI/: 45-85%), 28% (95% CI: 0-67%), 68% (95% CI: 20-81%) and 45% (95% CI: 0-66%), respectively. Measured and percent predicted FVC and FEV1 values showed no significant phenotypic correlations with AIx or aortic PWV, except for phenotypic twin correlations between measured FEV1, FVC with brachial or aortic augmentation indices which ranged between -0.12 and -0.17. No genetic covariance between lung function and arterial stiffness was found. Conclusions: Lung function is heritable and the measured FVC and FEV are phenotypically, but not genetically, associated with augmentation index, a measure of wave reflection. This relationship may in turn reveal further associations leading to a better mechanistic understanding of vascular changes in various airway diseases.

Original languageEnglish
Pages (from-to)927-935
Number of pages9
JournalRespiratory Medicine
Volume107
Issue number6
DOIs
StatePublished - Jun 1 2013

PMID: 23481174

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Genetic and environmental factors on the relation of lung function and arterial stiffness. / Tarnoki, David Laszlo; Tarnoki, Adam Domonkos; Lazar, Zsofia; Medda, Emanuela; Littvay, Levente; Cotichini, Rodolfo; Fagnani, Corrado; Stazi, Maria Antonietta; Nisticó, Lorenza; Lucatelli, Pierleone; Boatta, Emanuele; Zini, Chiara; Fanelli, Fabrizio; Baracchini, Claudio; Meneghetti, Giorgio; Jermendy, Gyorgy; Préda, István; Kiss, Róbert Gábor; Karlinger, Kinga; Lannert, Agnes; Schillaci, Giuseppe; Molnar, Andrea Agnes; Garami, Zsolt; Berczi, Viktor; Horvath, Ildiko.

In: Respiratory Medicine, Vol. 107, No. 6, 01.06.2013, p. 927-935.

Research output: Contribution to journalArticle

Harvard

Tarnoki, DL, Tarnoki, AD, Lazar, Z, Medda, E, Littvay, L, Cotichini, R, Fagnani, C, Stazi, MA, Nisticó, L, Lucatelli, P, Boatta, E, Zini, C, Fanelli, F, Baracchini, C, Meneghetti, G, Jermendy, G, Préda, I, Kiss, RG, Karlinger, K, Lannert, A, Schillaci, G, Molnar, AA, Garami, Z, Berczi, V & Horvath, I 2013, 'Genetic and environmental factors on the relation of lung function and arterial stiffness' Respiratory Medicine, vol. 107, no. 6, pp. 927-935. https://doi.org/10.1016/j.rmed.2013.02.002

APA

Tarnoki, D. L., Tarnoki, A. D., Lazar, Z., Medda, E., Littvay, L., Cotichini, R., ... Horvath, I. (2013). Genetic and environmental factors on the relation of lung function and arterial stiffness. Respiratory Medicine, 107(6), 927-935. https://doi.org/10.1016/j.rmed.2013.02.002

Vancouver

Tarnoki DL, Tarnoki AD, Lazar Z, Medda E, Littvay L, Cotichini R et al. Genetic and environmental factors on the relation of lung function and arterial stiffness. Respiratory Medicine. 2013 Jun 1;107(6):927-935. https://doi.org/10.1016/j.rmed.2013.02.002

Author

Tarnoki, David Laszlo ; Tarnoki, Adam Domonkos ; Lazar, Zsofia ; Medda, Emanuela ; Littvay, Levente ; Cotichini, Rodolfo ; Fagnani, Corrado ; Stazi, Maria Antonietta ; Nisticó, Lorenza ; Lucatelli, Pierleone ; Boatta, Emanuele ; Zini, Chiara ; Fanelli, Fabrizio ; Baracchini, Claudio ; Meneghetti, Giorgio ; Jermendy, Gyorgy ; Préda, István ; Kiss, Róbert Gábor ; Karlinger, Kinga ; Lannert, Agnes ; Schillaci, Giuseppe ; Molnar, Andrea Agnes ; Garami, Zsolt ; Berczi, Viktor ; Horvath, Ildiko. / Genetic and environmental factors on the relation of lung function and arterial stiffness. In: Respiratory Medicine. 2013 ; Vol. 107, No. 6. pp. 927-935.

BibTeX

@article{0d10ccec6c0b406081edd7030f5bbbeb,
title = "Genetic and environmental factors on the relation of lung function and arterial stiffness",
abstract = "Background: An association between reduced lung function and increased cardiovascular risk has been reported, but the underlying mechanisms are unknown. The aim of this study was to assess the heritability of lung function and to estimate its genetic association with arterial stiffness. Methods: 150 monozygotic and 42 dizygotic healthy Hungarian and American Caucasian twin pairs (age 43 ± 17 years) underwent spirometry (forced vital capacity/FVC/, forced expiratory volume in 1 s/FEV1/; MIR Minispir, USA); and their brachial and central augmentation indices (AIx), and aortic pulse wave velocity (PWV) were measured by oscillometric Arteriograph (TensioMed Ltd, Budapest, Hungary). Phenotypic correlations and bivariate Cholesky decomposition models were applied. Results: Age-, sex-, country- and smoking-adjusted heritability of FEV1, percent predicted FEV1, FVC and percent predicted FVC were 73{\%} (95{\%} confidence interval /CI/: 45-85{\%}), 28{\%} (95{\%} CI: 0-67{\%}), 68{\%} (95{\%} CI: 20-81{\%}) and 45{\%} (95{\%} CI: 0-66{\%}), respectively. Measured and percent predicted FVC and FEV1 values showed no significant phenotypic correlations with AIx or aortic PWV, except for phenotypic twin correlations between measured FEV1, FVC with brachial or aortic augmentation indices which ranged between -0.12 and -0.17. No genetic covariance between lung function and arterial stiffness was found. Conclusions: Lung function is heritable and the measured FVC and FEV are phenotypically, but not genetically, associated with augmentation index, a measure of wave reflection. This relationship may in turn reveal further associations leading to a better mechanistic understanding of vascular changes in various airway diseases.",
keywords = "Augmentation index, Forced vital capacity, Genetics, Pulmonary function test, Pulse wave velocity",
author = "Tarnoki, {David Laszlo} and Tarnoki, {Adam Domonkos} and Zsofia Lazar and Emanuela Medda and Levente Littvay and Rodolfo Cotichini and Corrado Fagnani and Stazi, {Maria Antonietta} and Lorenza Nistic{\'o} and Pierleone Lucatelli and Emanuele Boatta and Chiara Zini and Fabrizio Fanelli and Claudio Baracchini and Giorgio Meneghetti and Gyorgy Jermendy and Istv{\'a}n Pr{\'e}da and Kiss, {R{\'o}bert G{\'a}bor} and Kinga Karlinger and Agnes Lannert and Giuseppe Schillaci and Molnar, {Andrea Agnes} and Zsolt Garami and Viktor Berczi and Ildiko Horvath",
year = "2013",
month = "6",
day = "1",
doi = "10.1016/j.rmed.2013.02.002",
language = "English",
volume = "107",
pages = "927--935",
journal = "Respiratory Medicine",
issn = "0954-6111",
publisher = "W.B. Saunders Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Genetic and environmental factors on the relation of lung function and arterial stiffness

AU - Tarnoki, David Laszlo

AU - Tarnoki, Adam Domonkos

AU - Lazar, Zsofia

AU - Medda, Emanuela

AU - Littvay, Levente

AU - Cotichini, Rodolfo

AU - Fagnani, Corrado

AU - Stazi, Maria Antonietta

AU - Nisticó, Lorenza

AU - Lucatelli, Pierleone

AU - Boatta, Emanuele

AU - Zini, Chiara

AU - Fanelli, Fabrizio

AU - Baracchini, Claudio

AU - Meneghetti, Giorgio

AU - Jermendy, Gyorgy

AU - Préda, István

AU - Kiss, Róbert Gábor

AU - Karlinger, Kinga

AU - Lannert, Agnes

AU - Schillaci, Giuseppe

AU - Molnar, Andrea Agnes

AU - Garami, Zsolt

AU - Berczi, Viktor

AU - Horvath, Ildiko

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Background: An association between reduced lung function and increased cardiovascular risk has been reported, but the underlying mechanisms are unknown. The aim of this study was to assess the heritability of lung function and to estimate its genetic association with arterial stiffness. Methods: 150 monozygotic and 42 dizygotic healthy Hungarian and American Caucasian twin pairs (age 43 ± 17 years) underwent spirometry (forced vital capacity/FVC/, forced expiratory volume in 1 s/FEV1/; MIR Minispir, USA); and their brachial and central augmentation indices (AIx), and aortic pulse wave velocity (PWV) were measured by oscillometric Arteriograph (TensioMed Ltd, Budapest, Hungary). Phenotypic correlations and bivariate Cholesky decomposition models were applied. Results: Age-, sex-, country- and smoking-adjusted heritability of FEV1, percent predicted FEV1, FVC and percent predicted FVC were 73% (95% confidence interval /CI/: 45-85%), 28% (95% CI: 0-67%), 68% (95% CI: 20-81%) and 45% (95% CI: 0-66%), respectively. Measured and percent predicted FVC and FEV1 values showed no significant phenotypic correlations with AIx or aortic PWV, except for phenotypic twin correlations between measured FEV1, FVC with brachial or aortic augmentation indices which ranged between -0.12 and -0.17. No genetic covariance between lung function and arterial stiffness was found. Conclusions: Lung function is heritable and the measured FVC and FEV are phenotypically, but not genetically, associated with augmentation index, a measure of wave reflection. This relationship may in turn reveal further associations leading to a better mechanistic understanding of vascular changes in various airway diseases.

AB - Background: An association between reduced lung function and increased cardiovascular risk has been reported, but the underlying mechanisms are unknown. The aim of this study was to assess the heritability of lung function and to estimate its genetic association with arterial stiffness. Methods: 150 monozygotic and 42 dizygotic healthy Hungarian and American Caucasian twin pairs (age 43 ± 17 years) underwent spirometry (forced vital capacity/FVC/, forced expiratory volume in 1 s/FEV1/; MIR Minispir, USA); and their brachial and central augmentation indices (AIx), and aortic pulse wave velocity (PWV) were measured by oscillometric Arteriograph (TensioMed Ltd, Budapest, Hungary). Phenotypic correlations and bivariate Cholesky decomposition models were applied. Results: Age-, sex-, country- and smoking-adjusted heritability of FEV1, percent predicted FEV1, FVC and percent predicted FVC were 73% (95% confidence interval /CI/: 45-85%), 28% (95% CI: 0-67%), 68% (95% CI: 20-81%) and 45% (95% CI: 0-66%), respectively. Measured and percent predicted FVC and FEV1 values showed no significant phenotypic correlations with AIx or aortic PWV, except for phenotypic twin correlations between measured FEV1, FVC with brachial or aortic augmentation indices which ranged between -0.12 and -0.17. No genetic covariance between lung function and arterial stiffness was found. Conclusions: Lung function is heritable and the measured FVC and FEV are phenotypically, but not genetically, associated with augmentation index, a measure of wave reflection. This relationship may in turn reveal further associations leading to a better mechanistic understanding of vascular changes in various airway diseases.

KW - Augmentation index

KW - Forced vital capacity

KW - Genetics

KW - Pulmonary function test

KW - Pulse wave velocity

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UR - http://www.scopus.com/inward/citedby.url?scp=84877576754&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2013.02.002

DO - 10.1016/j.rmed.2013.02.002

M3 - Article

VL - 107

SP - 927

EP - 935

JO - Respiratory Medicine

T2 - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

IS - 6

ER -

ID: 3326608