Genetic and environmental effects on the abdominal aortic diameter development

Research output: Contribution to journalArticle

Adam Domonkos Tarnoki, David Laszlo Tarnoki, Levente Littvay, Zsolt Garami, Kinga Karlinger, Viktor Berczi

Background: Configuration of the abdominal aorta is related to healthy aging and a variety of disorders. Objectives: We aimed to assess heritable and environmental effects on the abdominal aortic diameter. Methods: 114 adult (69 monozygotic, 45 same-sex dizygotic) twin pairs (mean age 43.6 ± 16.3 years) underwent abdominal ultrasound with Esaote MyLab 70X ultrasound machine to visualize the abdominal aorta below the level of the origin of the renal arteries and 1-3 cm above the bifurcation. Results: Age- and sex-adjusted heritability of the abdominal aortic diameter below the level of the origin of the renal arteries was 40% [95% confidence interval (CI), 14 to 67%] and 55% above the aortic bifurcation (95% CI, 45 to 70%). None of the aortic diameters showed common environmental effects, but unshared environmental effects were responsible for 60% and 45% of the traits, respectively. Conclusions: Our analysis documents the moderate heritability and its segment-specific difference of the abdominal aortic diameter. The moderate part of variance was explained by unshared environmental components, emphasizing the importance of lifestyle factors in primary prevention. Further studies in this field may guide future gene-mapping efforts and investigate specific lifestyle factors to prevent abdominal aortic dilatation and its complications.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalArquivos Brasileiros de Cardiologia
Volume106
Issue number1
DOIs
StatePublished - Jan 1 2016

PMID: 26559855

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Genetic and environmental effects on the abdominal aortic diameter development. / Tarnoki, Adam Domonkos; Tarnoki, David Laszlo; Littvay, Levente; Garami, Zsolt; Karlinger, Kinga; Berczi, Viktor.

In: Arquivos Brasileiros de Cardiologia, Vol. 106, No. 1, 01.01.2016, p. 13-17.

Research output: Contribution to journalArticle

Harvard

Tarnoki, AD, Tarnoki, DL, Littvay, L, Garami, Z, Karlinger, K & Berczi, V 2016, 'Genetic and environmental effects on the abdominal aortic diameter development' Arquivos Brasileiros de Cardiologia, vol. 106, no. 1, pp. 13-17. https://doi.org/10.5935/abc.20150140

APA

Tarnoki, A. D., Tarnoki, D. L., Littvay, L., Garami, Z., Karlinger, K., & Berczi, V. (2016). Genetic and environmental effects on the abdominal aortic diameter development. Arquivos Brasileiros de Cardiologia, 106(1), 13-17. https://doi.org/10.5935/abc.20150140

Vancouver

Tarnoki AD, Tarnoki DL, Littvay L, Garami Z, Karlinger K, Berczi V. Genetic and environmental effects on the abdominal aortic diameter development. Arquivos Brasileiros de Cardiologia. 2016 Jan 1;106(1):13-17. https://doi.org/10.5935/abc.20150140

Author

Tarnoki, Adam Domonkos ; Tarnoki, David Laszlo ; Littvay, Levente ; Garami, Zsolt ; Karlinger, Kinga ; Berczi, Viktor. / Genetic and environmental effects on the abdominal aortic diameter development. In: Arquivos Brasileiros de Cardiologia. 2016 ; Vol. 106, No. 1. pp. 13-17.

BibTeX

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title = "Genetic and environmental effects on the abdominal aortic diameter development",
abstract = "Background: Configuration of the abdominal aorta is related to healthy aging and a variety of disorders. Objectives: We aimed to assess heritable and environmental effects on the abdominal aortic diameter. Methods: 114 adult (69 monozygotic, 45 same-sex dizygotic) twin pairs (mean age 43.6 ± 16.3 years) underwent abdominal ultrasound with Esaote MyLab 70X ultrasound machine to visualize the abdominal aorta below the level of the origin of the renal arteries and 1-3 cm above the bifurcation. Results: Age- and sex-adjusted heritability of the abdominal aortic diameter below the level of the origin of the renal arteries was 40{\%} [95{\%} confidence interval (CI), 14 to 67{\%}] and 55{\%} above the aortic bifurcation (95{\%} CI, 45 to 70{\%}). None of the aortic diameters showed common environmental effects, but unshared environmental effects were responsible for 60{\%} and 45{\%} of the traits, respectively. Conclusions: Our analysis documents the moderate heritability and its segment-specific difference of the abdominal aortic diameter. The moderate part of variance was explained by unshared environmental components, emphasizing the importance of lifestyle factors in primary prevention. Further studies in this field may guide future gene-mapping efforts and investigate specific lifestyle factors to prevent abdominal aortic dilatation and its complications.",
keywords = "Aorta, abdominal / genetics, Atherosclerosis, Heredity, Risk factors",
author = "Tarnoki, {Adam Domonkos} and Tarnoki, {David Laszlo} and Levente Littvay and Zsolt Garami and Kinga Karlinger and Viktor Berczi",
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RIS

TY - JOUR

T1 - Genetic and environmental effects on the abdominal aortic diameter development

AU - Tarnoki, Adam Domonkos

AU - Tarnoki, David Laszlo

AU - Littvay, Levente

AU - Garami, Zsolt

AU - Karlinger, Kinga

AU - Berczi, Viktor

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Configuration of the abdominal aorta is related to healthy aging and a variety of disorders. Objectives: We aimed to assess heritable and environmental effects on the abdominal aortic diameter. Methods: 114 adult (69 monozygotic, 45 same-sex dizygotic) twin pairs (mean age 43.6 ± 16.3 years) underwent abdominal ultrasound with Esaote MyLab 70X ultrasound machine to visualize the abdominal aorta below the level of the origin of the renal arteries and 1-3 cm above the bifurcation. Results: Age- and sex-adjusted heritability of the abdominal aortic diameter below the level of the origin of the renal arteries was 40% [95% confidence interval (CI), 14 to 67%] and 55% above the aortic bifurcation (95% CI, 45 to 70%). None of the aortic diameters showed common environmental effects, but unshared environmental effects were responsible for 60% and 45% of the traits, respectively. Conclusions: Our analysis documents the moderate heritability and its segment-specific difference of the abdominal aortic diameter. The moderate part of variance was explained by unshared environmental components, emphasizing the importance of lifestyle factors in primary prevention. Further studies in this field may guide future gene-mapping efforts and investigate specific lifestyle factors to prevent abdominal aortic dilatation and its complications.

AB - Background: Configuration of the abdominal aorta is related to healthy aging and a variety of disorders. Objectives: We aimed to assess heritable and environmental effects on the abdominal aortic diameter. Methods: 114 adult (69 monozygotic, 45 same-sex dizygotic) twin pairs (mean age 43.6 ± 16.3 years) underwent abdominal ultrasound with Esaote MyLab 70X ultrasound machine to visualize the abdominal aorta below the level of the origin of the renal arteries and 1-3 cm above the bifurcation. Results: Age- and sex-adjusted heritability of the abdominal aortic diameter below the level of the origin of the renal arteries was 40% [95% confidence interval (CI), 14 to 67%] and 55% above the aortic bifurcation (95% CI, 45 to 70%). None of the aortic diameters showed common environmental effects, but unshared environmental effects were responsible for 60% and 45% of the traits, respectively. Conclusions: Our analysis documents the moderate heritability and its segment-specific difference of the abdominal aortic diameter. The moderate part of variance was explained by unshared environmental components, emphasizing the importance of lifestyle factors in primary prevention. Further studies in this field may guide future gene-mapping efforts and investigate specific lifestyle factors to prevent abdominal aortic dilatation and its complications.

KW - Aorta, abdominal / genetics

KW - Atherosclerosis

KW - Heredity

KW - Risk factors

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DO - 10.5935/abc.20150140

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