Genetic and environmental effects on carotid flow velocities: Aninternational twin study

Research output: Contribution to journalArticle

Pierleone Lucatelli, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Maria Fabrizia Giannoni, Marianna Gazzetti, Emanuele Boatta, Chiara Zini, Rodolfo Cotichini, Claudio Baracchini, Giorgio Meneghetti, Lorenza Nisticó, Corrado Fagnani, Kinga Karlinger, Tamas Horvath, Andrea Agnes Molnar, Zsolt Garami, Emanuela Medda, Maria Antonietta Stazi, Viktor Berczi, Fabrizio Fanelli

Introduction: Altered carotid blood flow velocities (CFV) have a complex background but the underlying genetic contribution is still unclear. We sought to evaluate the influence of genetics, shared and unshared environmental components on individual differences of CFV. Methods: 193 healthy twin pairs, 126 monozygotic (MZ) and 67 dizygotic (DZ) (mean age 53±14 years) recruited in Italy, in the United States and in Hungary underwent bilateral color-coded Doppler flow assessment of the common carotid artery (CCA) and of the internal carotid artery (ICA) in order to assess the peak systolic (PSV) and end diastolic (EDV) velocities. Means of bilateral CFV values were used in the analysis. Results: Age- and country-adjusted intra-class correlations were higher in monozygotic than in dizygotic pairs for mean PSV of the ICA indicating a heritability of 63%. Unique environmental factors contributed to 37% of ICA PSV. With regards to the mean PSV and EDV of the CCA, and EDV of the ICA, heritability analysis indicated no discernible role for genetic components, while the contributions of shared and unshared environmental factors ranged between 56% and 63%, and between 37% and 44% adjusted for age and country, respectively. Mean ICA/CCA ratio was driven by unique environmental factors (82%) with modest heritability (18%). Conclusions: Our study showed that the heritability of ICA PSV and ICA/CCA ratio is moderate, while the findings do not support heritability of other investigated CFV values. Environmental effects account for a moderate to major portion of the variance. These findings support the value of early ultrasound screening as well as the prevention of modifiable environmental factors in case of altered carotid flow velocities.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalAtherosclerosis
Volume231
Issue number2
DOIs
StatePublished - Dec 1 2013

PMID: 24267227

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Genetic and environmental effects on carotid flow velocities : Aninternational twin study. / Lucatelli, Pierleone; Tarnoki, Adam Domonkos; Tarnoki, David Laszlo; Giannoni, Maria Fabrizia; Gazzetti, Marianna; Boatta, Emanuele; Zini, Chiara; Cotichini, Rodolfo; Baracchini, Claudio; Meneghetti, Giorgio; Nisticó, Lorenza; Fagnani, Corrado; Karlinger, Kinga; Horvath, Tamas; Molnar, Andrea Agnes; Garami, Zsolt; Medda, Emanuela; Stazi, Maria Antonietta; Berczi, Viktor; Fanelli, Fabrizio.

In: Atherosclerosis, Vol. 231, No. 2, 01.12.2013, p. 205-210.

Research output: Contribution to journalArticle

Harvard

Lucatelli, P, Tarnoki, AD, Tarnoki, DL, Giannoni, MF, Gazzetti, M, Boatta, E, Zini, C, Cotichini, R, Baracchini, C, Meneghetti, G, Nisticó, L, Fagnani, C, Karlinger, K, Horvath, T, Molnar, AA, Garami, Z, Medda, E, Stazi, MA, Berczi, V & Fanelli, F 2013, 'Genetic and environmental effects on carotid flow velocities: Aninternational twin study' Atherosclerosis, vol. 231, no. 2, pp. 205-210. https://doi.org/10.1016/j.atherosclerosis.2013.08.032

APA

Lucatelli, P., Tarnoki, A. D., Tarnoki, D. L., Giannoni, M. F., Gazzetti, M., Boatta, E., ... Fanelli, F. (2013). Genetic and environmental effects on carotid flow velocities: Aninternational twin study. Atherosclerosis, 231(2), 205-210. https://doi.org/10.1016/j.atherosclerosis.2013.08.032

Vancouver

Lucatelli P, Tarnoki AD, Tarnoki DL, Giannoni MF, Gazzetti M, Boatta E et al. Genetic and environmental effects on carotid flow velocities: Aninternational twin study. Atherosclerosis. 2013 Dec 1;231(2):205-210. https://doi.org/10.1016/j.atherosclerosis.2013.08.032

Author

Lucatelli, Pierleone ; Tarnoki, Adam Domonkos ; Tarnoki, David Laszlo ; Giannoni, Maria Fabrizia ; Gazzetti, Marianna ; Boatta, Emanuele ; Zini, Chiara ; Cotichini, Rodolfo ; Baracchini, Claudio ; Meneghetti, Giorgio ; Nisticó, Lorenza ; Fagnani, Corrado ; Karlinger, Kinga ; Horvath, Tamas ; Molnar, Andrea Agnes ; Garami, Zsolt ; Medda, Emanuela ; Stazi, Maria Antonietta ; Berczi, Viktor ; Fanelli, Fabrizio. / Genetic and environmental effects on carotid flow velocities : Aninternational twin study. In: Atherosclerosis. 2013 ; Vol. 231, No. 2. pp. 205-210.

BibTeX

@article{1864d6e494ef4442a2e911b9c2d93c79,
title = "Genetic and environmental effects on carotid flow velocities: Aninternational twin study",
abstract = "Introduction: Altered carotid blood flow velocities (CFV) have a complex background but the underlying genetic contribution is still unclear. We sought to evaluate the influence of genetics, shared and unshared environmental components on individual differences of CFV. Methods: 193 healthy twin pairs, 126 monozygotic (MZ) and 67 dizygotic (DZ) (mean age 53±14 years) recruited in Italy, in the United States and in Hungary underwent bilateral color-coded Doppler flow assessment of the common carotid artery (CCA) and of the internal carotid artery (ICA) in order to assess the peak systolic (PSV) and end diastolic (EDV) velocities. Means of bilateral CFV values were used in the analysis. Results: Age- and country-adjusted intra-class correlations were higher in monozygotic than in dizygotic pairs for mean PSV of the ICA indicating a heritability of 63{\%}. Unique environmental factors contributed to 37{\%} of ICA PSV. With regards to the mean PSV and EDV of the CCA, and EDV of the ICA, heritability analysis indicated no discernible role for genetic components, while the contributions of shared and unshared environmental factors ranged between 56{\%} and 63{\%}, and between 37{\%} and 44{\%} adjusted for age and country, respectively. Mean ICA/CCA ratio was driven by unique environmental factors (82{\%}) with modest heritability (18{\%}). Conclusions: Our study showed that the heritability of ICA PSV and ICA/CCA ratio is moderate, while the findings do not support heritability of other investigated CFV values. Environmental effects account for a moderate to major portion of the variance. These findings support the value of early ultrasound screening as well as the prevention of modifiable environmental factors in case of altered carotid flow velocities.",
keywords = "Atherosclerosis, Carotid velocities, Heritability, Twins",
author = "Pierleone Lucatelli and Tarnoki, {Adam Domonkos} and Tarnoki, {David Laszlo} and Giannoni, {Maria Fabrizia} and Marianna Gazzetti and Emanuele Boatta and Chiara Zini and Rodolfo Cotichini and Claudio Baracchini and Giorgio Meneghetti and Lorenza Nistic{\'o} and Corrado Fagnani and Kinga Karlinger and Tamas Horvath and Molnar, {Andrea Agnes} and Zsolt Garami and Emanuela Medda and Stazi, {Maria Antonietta} and Viktor Berczi and Fabrizio Fanelli",
year = "2013",
month = "12",
day = "1",
doi = "10.1016/j.atherosclerosis.2013.08.032",
language = "English",
volume = "231",
pages = "205--210",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Genetic and environmental effects on carotid flow velocities

T2 - Atherosclerosis

AU - Lucatelli, Pierleone

AU - Tarnoki, Adam Domonkos

AU - Tarnoki, David Laszlo

AU - Giannoni, Maria Fabrizia

AU - Gazzetti, Marianna

AU - Boatta, Emanuele

AU - Zini, Chiara

AU - Cotichini, Rodolfo

AU - Baracchini, Claudio

AU - Meneghetti, Giorgio

AU - Nisticó, Lorenza

AU - Fagnani, Corrado

AU - Karlinger, Kinga

AU - Horvath, Tamas

AU - Molnar, Andrea Agnes

AU - Garami, Zsolt

AU - Medda, Emanuela

AU - Stazi, Maria Antonietta

AU - Berczi, Viktor

AU - Fanelli, Fabrizio

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Introduction: Altered carotid blood flow velocities (CFV) have a complex background but the underlying genetic contribution is still unclear. We sought to evaluate the influence of genetics, shared and unshared environmental components on individual differences of CFV. Methods: 193 healthy twin pairs, 126 monozygotic (MZ) and 67 dizygotic (DZ) (mean age 53±14 years) recruited in Italy, in the United States and in Hungary underwent bilateral color-coded Doppler flow assessment of the common carotid artery (CCA) and of the internal carotid artery (ICA) in order to assess the peak systolic (PSV) and end diastolic (EDV) velocities. Means of bilateral CFV values were used in the analysis. Results: Age- and country-adjusted intra-class correlations were higher in monozygotic than in dizygotic pairs for mean PSV of the ICA indicating a heritability of 63%. Unique environmental factors contributed to 37% of ICA PSV. With regards to the mean PSV and EDV of the CCA, and EDV of the ICA, heritability analysis indicated no discernible role for genetic components, while the contributions of shared and unshared environmental factors ranged between 56% and 63%, and between 37% and 44% adjusted for age and country, respectively. Mean ICA/CCA ratio was driven by unique environmental factors (82%) with modest heritability (18%). Conclusions: Our study showed that the heritability of ICA PSV and ICA/CCA ratio is moderate, while the findings do not support heritability of other investigated CFV values. Environmental effects account for a moderate to major portion of the variance. These findings support the value of early ultrasound screening as well as the prevention of modifiable environmental factors in case of altered carotid flow velocities.

AB - Introduction: Altered carotid blood flow velocities (CFV) have a complex background but the underlying genetic contribution is still unclear. We sought to evaluate the influence of genetics, shared and unshared environmental components on individual differences of CFV. Methods: 193 healthy twin pairs, 126 monozygotic (MZ) and 67 dizygotic (DZ) (mean age 53±14 years) recruited in Italy, in the United States and in Hungary underwent bilateral color-coded Doppler flow assessment of the common carotid artery (CCA) and of the internal carotid artery (ICA) in order to assess the peak systolic (PSV) and end diastolic (EDV) velocities. Means of bilateral CFV values were used in the analysis. Results: Age- and country-adjusted intra-class correlations were higher in monozygotic than in dizygotic pairs for mean PSV of the ICA indicating a heritability of 63%. Unique environmental factors contributed to 37% of ICA PSV. With regards to the mean PSV and EDV of the CCA, and EDV of the ICA, heritability analysis indicated no discernible role for genetic components, while the contributions of shared and unshared environmental factors ranged between 56% and 63%, and between 37% and 44% adjusted for age and country, respectively. Mean ICA/CCA ratio was driven by unique environmental factors (82%) with modest heritability (18%). Conclusions: Our study showed that the heritability of ICA PSV and ICA/CCA ratio is moderate, while the findings do not support heritability of other investigated CFV values. Environmental effects account for a moderate to major portion of the variance. These findings support the value of early ultrasound screening as well as the prevention of modifiable environmental factors in case of altered carotid flow velocities.

KW - Atherosclerosis

KW - Carotid velocities

KW - Heritability

KW - Twins

UR - http://www.scopus.com/inward/record.url?scp=84888113974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888113974&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2013.08.032

DO - 10.1016/j.atherosclerosis.2013.08.032

M3 - Article

VL - 231

SP - 205

EP - 210

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -

ID: 2940614