Genetic analysis of voltage-dependent calcium channels

Research output: Contribution to journalShort survey

11 Scopus citations

Abstract

Molecular cloning of calcium channel subunit genes has identified an unexpectedly large number of genes and splicing variants, and a central problem of calcium channel biology is to now understand the functional significance of this genetic complexity. While electrophyisological, pharmacological, and molecular cloning techniques are providing one level of understanding, a complete understanding will require many additional kinds of studies, including genetic studies done in intact animals. In this regard, an intriguing variety of episodic diseases have recently been identified that result from defects in calcium channel genes. A study of these diseases illustrates the kind of insights into calcium channel function that can be expected from this method of inquiry.

Original languageEnglish (US)
Pages (from-to)387-398
Number of pages12
JournalJournal of Bioenergetics and Biomembranes
Volume30
Issue number4
DOIs
StatePublished - 1998

Keywords

  • Calcium release channels
  • Disease loci
  • Mutations
  • Paroxsymal disorders
  • Triplet repeats
  • Voltage-dependent calcium channels

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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