@article{211b2e5680524fd99d47030d1407872f,
title = "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease",
abstract = "The proneural protein Neurogenin 2 (NEUROG2) is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons. To determine whether genetic variation in the coding region of the NEUROG2 gene plays a role in the etiology of Parkinson's disease (PD), we screened DNA samples from 202 PD patients and 201 normal controls. No mutation in the NEUROG2 gene was identified in our PD cohort, except that novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.",
keywords = "Coding region, Mutation, NEUROG2, Parkinson's disease, Transcription factor",
author = "Sheng Deng and Hao Deng and Weidong Le and Hongbo Xu and Huarong Yang and Xiong Deng and Hongwei Lv and Wenjie Xie and Shaihong Zhu and Joseph Jankovic",
note = "Funding Information: This study was supported by the foundation for build-up of key disciplines from the Education Department of Hunan Province (S.D.), the Fund of Hunan Province for Distinguished Young Scholar (09JJI005), Program for New Century Excellent Talents in University of Ministry of Education of P.R. China (NCET-080563), Sheng Hua Scholars Program and Outstanding Youth Foundation of Central South University, China (H.D.), the Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (H.D.), National Natural Science Foundation of China (30871351), Parkinson's and Movement Disorder Foundation (H.D.), the Diana Helis Henry Medical Research Foundation (W.L.) and the National Parkinson Foundation to the Baylor College of Medicine Center of Excellence (J.J.). The authors thank the participating patients for their cooperation, and thank Dr. William Ondo (Parkinson Disease Center and Movement Disorder Clinic, Baylor College of Medicine, Houston, TX) for their efforts in collecting the genetic information and DNA specimens.",
year = "2010",
month = jan,
day = "14",
doi = "10.1016/j.neulet.2009.10.078",
language = "English (US)",
volume = "468",
pages = "195--197",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",
}