Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease

Sheng Deng, Hao Deng, Weidong Le, Hongbo Xu, Huarong Yang, Xiong Deng, Hongwei Lv, Wenjie Xie, Shaihong Zhu, Joseph Jankovic

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The proneural protein Neurogenin 2 (NEUROG2) is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons. To determine whether genetic variation in the coding region of the NEUROG2 gene plays a role in the etiology of Parkinson's disease (PD), we screened DNA samples from 202 PD patients and 201 normal controls. No mutation in the NEUROG2 gene was identified in our PD cohort, except that novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD.

Original languageEnglish (US)
Pages (from-to)195-197
Number of pages3
JournalNeuroscience Letters
Volume468
Issue number3
DOIs
StatePublished - Jan 14 2010

Keywords

  • Coding region
  • Mutation
  • NEUROG2
  • Parkinson's disease
  • Transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)

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