Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism

Hao Deng, Weidong Le, Wen Jie Xie, Tian Hong Pan, Xiong Zhang, Joseph Jankovic

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Parkin co-regulated gene (PACRG) is a recently identified gene which is transcriptionally co-regulated with parkin gene (PRKN) by a shared bidirectional promoter. To determine whether early-onset parkinsonism (EOP) is associated with PACRG mutation, we screened 112 patients with EOP and found three nucleotide variants: (1) T>C transition in intron 2 (nt 87004; NT_007422), (2) C>T transition (L214L) in exon 6 (nt 585706; NT_007422), and (3) T>A substitution in intron 5 (nt 585630; NT_007422), located 18 bp upstream from exon 6. Since none of these variations appear to be pathogenically relevant, our results suggest that mutation of PACRG plays little or no role in the development of EOP.

Original languageEnglish (US)
Pages (from-to)297-299
Number of pages3
JournalNeuroscience Letters
Volume382
Issue number3
DOIs
StatePublished - Jul 15 2005

Keywords

  • Early-onset parkinsonism
  • Genetic analysis
  • Parkin co-regulated gene
  • Variant

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism'. Together they form a unique fingerprint.

Cite this