Genetic analysis of NR4A2 gene in a large population of Han Chinese patients with Parkinson's disease

H. Liu, Q. Tao, H. Deng, M. Ming, Y. Ding, P. Xu, S. Chen, Z. Song, W. Le

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: NR4A2 gene is a transcription factor crucial for differentiation and survival of midbrain dopamine (DA) neurons, and several variants have been eported to be associated with Parkinson's disease (PD) in the Caucasian population. Methods: To determine whether there is any association of NR4A2 mutation or variation with PD in the Han Chinese population, we performed a genetic analysis of all the exons and exon-intron boundaries in 689 PD patients and 672 controls from mainland China using direct sequencing analysis. Results: We identified four novel variants and two previously reported variants. Two novel variants (exon 2 c.-20 C>G and exon 3 c.711 C>A) were only found in PD. The others (exon 2 c.-35 A>G; exon 8 c.1615 G>A; intron 4 IVS4-16 G>T; and intron 6 IVS6 + 18 insG) were found in both PD and controls at different frequencies. Conclusions: Collectively, our results suggest that NR4A2 may be a susceptibility gene for PD in the Chinese population.

Original languageEnglish (US)
Pages (from-to)584-587
Number of pages4
JournalEuropean Journal of Neurology
Volume20
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • Genetic analysis
  • NR4A2 gene
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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