Genetic analysis and developmental regulation of testis-specific RNA expression of Mos, Abl, actin and Hox-1.4

F. Propst, M. P. Rosenberg, M. K. Oskarsson, L. B. Russell, M. C. Nguyen-Huu, J. Nadeau, Nancy A. Jenkins, Neal G. Copeland, G. F. Vande Woude

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The pattern of Mos proto-oncogene RNA expression in the gonads of the sterile mouse mutants, dominant spotting (W), sex reversal (Sxr), testicular feminization (Tfm), hypogonadal (hpg), quaking (qk), two t-haplotypes, three X-autosomal translocations, and the Y(POS) strain, is consistent with its presence in haploid spermatids in the testes and in oocytes in the ovaries. In the male-sterile mouse mutants the pattern of expression of the testis-specific transcripts for Abl, actin, and the mouse homeobox Hox-1.4 genes is identical to that observed for Mos. However, during the postnatal onset of normal spermatogenesis we detected differences in the time of the appearance of the four transcripts. We detected Hox-1.4 transcripts at day 20, Mos at day 25, and Abl and actin at day 30, demonstrating a specific regulation of expression of each of these genes during haploid spermatid maturation in the mouse. Furthermore, comparison of Mos, Abl and actin RNA expression in mouse and rat testes revealed species-specific variations in the regulation of gene expression.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalOncogene
Volume2
Issue number3
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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