@article{36c44d79c71746109c8909d8ccc8cb37,
title = "Generation of patient-derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas",
abstract = "One of the limitations of performing percutaneous biopsies in patients with bone sarcomas is the small amount of tumor that can be obtained for research purposes. Here, we describe our experience developing patient-derived tumor xenografts (PDXs) using percutaneous tumor biopsies in children with bone sarcomas. We generated 14 bone sarcoma PDXs from percutaneous tumor biopsies. We also developed eight bone sarcoma PDXs from surgical resection of primary bone tumors and pulmonary metastases. A multidisciplinary team approach was critical to establish an accurate diagnosis and to provide adequate tumor samples for PDX generation.",
keywords = "ewing sarcoma, osteosarcoma, patient-derived tumor xenograft, percutaneous biopsies",
author = "Nino Rainusso and Heather Cleveland and Hernandez, {J. Alberto} and Quintanilla, {Norma M.} and John Hicks and Sanjeev Vasudevan and Marco, {Rex A.W.} and Wendy Allen-Rhoades and Wang, {Lisa L.} and Yustein, {Jason T.}",
note = "Funding Information: Nino Rainusso is supported by St. Baldrick's Foundation and Snowdrop Foundation. Sanjeev Vasudevan is supported by Macy Easom Cancer Research Foundation grant. Wendy Allen-Rhoades is supported by Hyundai Hope on Wheels, Laurel's Army Foundation, and The Houston Tri Delta Alumnae. Lisa L. Wang is supported by Cookies for Kids{\textquoteright} Cancer. Jason T. Yustein is supported by R01 CA215452, R03 CA215940, Funding Information: informationGrant sponsor: St. Baldrick's Foundation, Grant sponsor: National Institutes of Health, Grant numbers: R01 CA215452, R03 CA215940, Grant sponsor: Snowdrop Foundation, Grant sponsor: Rally Foundation, Grant sponsor: Hyundai Scholar Hope Grant, Grant sponsor: Faris D. Virani Ewing Sarcoma CenterNino Rainusso is supported by St. Baldrick's Foundation and Snowdrop Foundation. Sanjeev Vasudevan is supported by Macy Easom Cancer Research Foundation grant. Wendy Allen-Rhoades is supported by Hyundai Hope on Wheels, Laurel's Army Foundation, and The Houston Tri Delta Alumnae. Lisa L. Wang is supported by Cookies for Kids? Cancer. Jason T. Yustein is supported by R01 CA215452, R03 CA215940, Alan B. Slifka Foundation, Rally Foundation, Hyundai Scholar Hope Grant, and Faris D. Virani Ewing Sarcoma Center. Funding Information: Grant sponsor: St. Baldrick's Foundation, Grant sponsor: National Institutes of Health, Grant numbers: R01 CA215452, R03 CA215940, Grant sponsor: Snowdrop Foundation, Grant sponsor: Rally Foundation, Grant sponsor: Hyundai Scholar Hope Grant, Grant sponsor: Faris D. Virani Ewing Sarcoma Center This work was presented previously at the 2nd Pediatric Precision Oncology Conference in Scottsdale, Arizona in March 2018. Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2019",
month = apr,
doi = "10.1002/pbc.27579",
language = "English (US)",
volume = "66",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley",
number = "4",
}