Generation of patient-derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas

Nino Rainusso, Heather Cleveland, J. Alberto Hernandez, Norma M. Quintanilla, John Hicks, Sanjeev Vasudevan, Rex A.W. Marco, Wendy Allen-Rhoades, Lisa L. Wang, Jason T. Yustein

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

One of the limitations of performing percutaneous biopsies in patients with bone sarcomas is the small amount of tumor that can be obtained for research purposes. Here, we describe our experience developing patient-derived tumor xenografts (PDXs) using percutaneous tumor biopsies in children with bone sarcomas. We generated 14 bone sarcoma PDXs from percutaneous tumor biopsies. We also developed eight bone sarcoma PDXs from surgical resection of primary bone tumors and pulmonary metastases. A multidisciplinary team approach was critical to establish an accurate diagnosis and to provide adequate tumor samples for PDX generation.

Original languageEnglish (US)
Article numbere27579
JournalPediatric Blood and Cancer
Volume66
Issue number4
DOIs
StatePublished - Apr 1 2019

Keywords

  • ewing sarcoma
  • osteosarcoma
  • patient-derived tumor xenograft
  • percutaneous biopsies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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