Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage

Eris Bidollari; Giovannina Rotundo; Daniela Ferrari; Ornella Candido; Laura Bernardini; Federica Consoli; Alessandro De Luca; Iolanda Santimone; Giuseppe Lamorte; Andrea Ilari; Ferdinando Squitieri; Angelo Luigi Vescovi; Jessica Rosati

doi:10.1016/j.scr.2018.02.014

Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage

Eris Bidollari, Giovannina Rotundo, Daniela Ferrari, Ornella Candido, Laura Bernardini, Federica Consoli, Alessandro De Luca, Iolanda Santimone, Giuseppe Lamorte, Andrea Ilari, Ferdinando Squitieri, Angelo Luigi Vescovi, Jessica Rosati

Academic Institute

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Huntington's disease (HD) is an incurable, autosomal dominant, hereditary neurodegenerative disorder that typically manifests itself in midlife. This pathology is linked to the deregulation of multiple, as yet unknown, cellular processes starting before HD onset. A human iPS cell line was generated from skin fibroblasts of a subject at the presymptomatic life stage, carrying a polyglutamine expansion in HTT gene codifying Huntingtin protein. The iPSC line contained the expected CAG expansion, expressed the expected pluripotency markers, displayed in vivo differentiation potential to the three germ layers and had a normal karyotype.

Original language	English (US)
Pages (from-to)	145-148
Number of pages	4
Journal	Stem Cell Research
Volume	28
DOIs	https://doi.org/10.1016/j.scr.2018.02.014
State	Published - Apr 2018

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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Bidollari, E., Rotundo, G., Ferrari, D., Candido, O., Bernardini, L., Consoli, F., De Luca, A., Santimone, I., Lamorte, G., Ilari, A., Squitieri, F., Vescovi, A. L., & Rosati, J. (2018). Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage. Stem Cell Research, 28, 145-148. https://doi.org/10.1016/j.scr.2018.02.014

Bidollari, E, Rotundo, G, Ferrari, D, Candido, O, Bernardini, L, Consoli, F, De Luca, A, Santimone, I, Lamorte, G, Ilari, A, Squitieri, F, Vescovi, AL & Rosati, J 2018, 'Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage', Stem Cell Research, vol. 28, pp. 145-148. https://doi.org/10.1016/j.scr.2018.02.014

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abstract = "Huntington's disease (HD) is an incurable, autosomal dominant, hereditary neurodegenerative disorder that typically manifests itself in midlife. This pathology is linked to the deregulation of multiple, as yet unknown, cellular processes starting before HD onset. A human iPS cell line was generated from skin fibroblasts of a subject at the presymptomatic life stage, carrying a polyglutamine expansion in HTT gene codifying Huntingtin protein. The iPSC line contained the expected CAG expansion, expressed the expected pluripotency markers, displayed in vivo differentiation potential to the three germ layers and had a normal karyotype.",

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doi = "10.1016/j.scr.2018.02.014",

language = "English (US)",

volume = "28",

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AU - Bidollari, Eris

AU - Rotundo, Giovannina

AU - Ferrari, Daniela

AU - Candido, Ornella

AU - Bernardini, Laura

AU - Consoli, Federica

AU - De Luca, Alessandro

AU - Santimone, Iolanda

AU - Lamorte, Giuseppe

AU - Ilari, Andrea

AU - Squitieri, Ferdinando

AU - Vescovi, Angelo Luigi

AU - Rosati, Jessica

PY - 2018/4

Y1 - 2018/4

N2 - Huntington's disease (HD) is an incurable, autosomal dominant, hereditary neurodegenerative disorder that typically manifests itself in midlife. This pathology is linked to the deregulation of multiple, as yet unknown, cellular processes starting before HD onset. A human iPS cell line was generated from skin fibroblasts of a subject at the presymptomatic life stage, carrying a polyglutamine expansion in HTT gene codifying Huntingtin protein. The iPSC line contained the expected CAG expansion, expressed the expected pluripotency markers, displayed in vivo differentiation potential to the three germ layers and had a normal karyotype.

AB - Huntington's disease (HD) is an incurable, autosomal dominant, hereditary neurodegenerative disorder that typically manifests itself in midlife. This pathology is linked to the deregulation of multiple, as yet unknown, cellular processes starting before HD onset. A human iPS cell line was generated from skin fibroblasts of a subject at the presymptomatic life stage, carrying a polyglutamine expansion in HTT gene codifying Huntingtin protein. The iPSC line contained the expected CAG expansion, expressed the expected pluripotency markers, displayed in vivo differentiation potential to the three germ layers and had a normal karyotype.

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ER -

Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage

Abstract

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