Gene therapy of pediatric leukemia

Research output: Contribution to journalReview articlepeer-review

Abstract

Gene therapy approaches offer the possibility of adding a treatment modality that is non-cross-reactive with chemotherapy to the therapeutic options for children with leukemia. Current strategies under evaluation in preclinical models include modification of leukemia cells to decrease tumorogenicity or increase immunogenicity and gene transfer to immune system cells to enhance immune function. Some of these approaches are now being evaluated in clinical trials.

Original languageEnglish (US)
Pages (from-to)183-195
Number of pages13
JournalClinics in Laboratory Medicine
Volume20
Issue number1
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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