TY - JOUR
T1 - Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein
AU - Birkeland, Marian L.
AU - Copeland, Neal G.
AU - Gilbert, Debra J.
AU - Jenkins, Nancy A.
AU - Barclay, A. Neil
PY - 1995/4
Y1 - 1995/4
N2 - The OX40 protein is expressed only on activated rat CD-4+ T blasts and is a member of a superfamily of cell surface molecules which includes CD-40, CD30, CD95 (Fas), CD27, 4-1BB antigens and the receptors for tumor necrosis factor (TNF) and nerve growth factor (NGF). The proteins of this group are related to each other by having three to six repeats of a cysteine-rich sequence in their extracellular domains. Members of this family of receptors have also been shown to bind to ligands which are structurally related to TNF. The mouse homologue of the rat OX40 protein was cloned at the cDNA and genomic levels. The gene structure shows that there are several intron/exon borders shared between OX40 and CD27, CD40, TNF receptor type I, CD95 and 4-1BB genes. This group of genes is less closely related structurally to the gene structure of the NGF receptor. The gene encoding murine OX40 has been placed on mouse chromosome 4, in an area which contains the genes for TNF receptor type II and 4-1BB, and is syntenic with a region of human chromosome 4 which contains human TNF receptor type II, OX40, and CD30 genes.
AB - The OX40 protein is expressed only on activated rat CD-4+ T blasts and is a member of a superfamily of cell surface molecules which includes CD-40, CD30, CD95 (Fas), CD27, 4-1BB antigens and the receptors for tumor necrosis factor (TNF) and nerve growth factor (NGF). The proteins of this group are related to each other by having three to six repeats of a cysteine-rich sequence in their extracellular domains. Members of this family of receptors have also been shown to bind to ligands which are structurally related to TNF. The mouse homologue of the rat OX40 protein was cloned at the cDNA and genomic levels. The gene structure shows that there are several intron/exon borders shared between OX40 and CD27, CD40, TNF receptor type I, CD95 and 4-1BB genes. This group of genes is less closely related structurally to the gene structure of the NGF receptor. The gene encoding murine OX40 has been placed on mouse chromosome 4, in an area which contains the genes for TNF receptor type II and 4-1BB, and is syntenic with a region of human chromosome 4 which contains human TNF receptor type II, OX40, and CD30 genes.
KW - Chromosome 4
KW - Gene
KW - Mouse
KW - OX40
UR - http://www.scopus.com/inward/record.url?scp=0028905896&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028905896&partnerID=8YFLogxK
U2 - 10.1002/eji.1830250410
DO - 10.1002/eji.1830250410
M3 - Article
C2 - 7737295
AN - SCOPUS:0028905896
SN - 0014-2980
VL - 25
SP - 926
EP - 930
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 4
ER -