Gene-marking and haemopoietic stem-cell transplantation

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Gene transfer has allowed a number of biological issues in haematopoietic stem-cell transplantation to be addressed. Gene-marking studies have shown that residual malignant cells in infused marrow may contribute to relapse in acute myeloid leukaemia, neuroblastoma and chronic myeloid leukaemia. Double gene-marking techniques with distinguishable retroviral vectors are being used to compare purging techniques and the reconstitution of different sources of stem cells. In allogeneic bone-marrow transplantation, gene-marking has demonstrated that adoptively transferred cytotoxic T cells can persist and reconstitute antiviral immunity.

Original languageEnglish (US)
Pages (from-to)220-225
Number of pages6
JournalBlood Reviews
Volume9
Issue number4
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Hematology
  • Oncology

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