Gene marking and gene therapy for transplantation medicine

Dagmar Dilloo, Donna R. Rill, Michael E. Grossmann, Thasia Leimig, Malcolm K. Brenner

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The classic application for gene therapy is in the the correction of single gene defects, although this has been complicated by the low efficiency of gene transfer into hematopoietic cells. Gene therapy, however, has potential for the modulation of tumor cell growth, drug sensitivity, and antitumor immune responses. In addition, gene marking can be used, in spite of this limited transfer efficiency, to provide information on hematopoiesis, sources of cancer relapse after stem cell transplant, and the relative efficacy of graft manipulation techniques. This article reviews the applications of gene therapy and gene marking in transplantation medicine.

Original languageEnglish (US)
Pages (from-to)553-555
Number of pages3
JournalJournal of Hematotherapy and Stem Cell Research
Volume5
Issue number5
DOIs
StatePublished - Oct 1996

ASJC Scopus subject areas

  • Immunology
  • Hematology

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