Gene Expression Regulation: Steroid Hormone Effects

Margaret Warner, S. Andersson, Jan-Ake Gustafsson

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Estradiol-17 β influences a wide variety of brain functions in mammals, including development, plasticity, feedback regulation of hypothalamic and pituitary hormone secretion, motor behavior, mood, and mental state, by the control of central aminergic and peptidergic neurotransmission, preservation of cognitive brain function, and perhaps neuroprotection in some neurological disorders, such as Alzheimer's disease, Parkinson's disease, and ischemic stroke. Estrogen action is exerted via both estrogen receptor (ER) α and β, encoded by different genes. A central finding is that ER. β is important for neuronal survival, during both brain development and the ensuing neuronal life span. An estrogenic metabolite of 5 α-dihydrotestosterone, 5 α-androstane-3. β,17. β-diol (3. βAdiol), appears to be an important ER. β ligand in the brain.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
Number of pages7
ISBN (Print)9780080450469
StatePublished - Jan 1 2009


  • Alzheimer's disease
  • Apoptosis
  • Cognition
  • Cytochrome P-450 7B1
  • ER knockout mice
  • Estrogen receptors α and β
  • Ischemic stroke
  • Mood
  • Neuroprotection
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)


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