Gene expression changes in peripheral blood from chinese han patients with tourette syndrome

Jing Lei, Hongbo Xu, Hui Liang, Linyan Su, Jie Zhang, Xian Huang, Zhi Song, Weidong Le, Hao Deng

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

To evaluate whether gene expression in chromosome 15q13-q22.3 region is responsible for the development of Tourette syndrome (TS). Eighty-four unrelated Chinese Han patients with TS (male/female=68/16; mean age 9.92±3.98 years) and 100 sex, age, and ethnicity matched normal controls (male/female=80/20; mean age 10.90±5.86 years) were enrolled in this study. We performed quantitative real-time PCR on a subset of seven genes: the L-histidine decarboxylase gene (HDC), the HECT domain and RCC-1 like domain 1 gene (HERC1), the HECT domain and RCC-1 like domain 2 gene (HERC2), the cholinergic receptor, neuronal nicotinic alpha polypeptide 7 gene (CHRNA7), the ubiquitin protein ligase E3A gene (UBE3A), the ubiquitin specific peptidase 3 gene (USP3) and the amyloid precursor protein-binding protein A2 gene (APBA2) previously reported to be stably expressed in brain tissue. A significant difference was shown for the APBA2 gene expression of peripheral lymphocytes between Chinese Han TS group and healthy controls (relative expression: 0.21±0.16-fold decrease in patients versus normal, P<0.01). Indicating that the APBA2 gene is a promising peripheral blood biomarker that discriminates between patients with TS and healthy subjects. Further studies into this gene and its protein products may provide insights into the pathogenesis of TS.

Original languageEnglish (US)
Pages (from-to)977-980
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume159 B
Issue number8
DOIs
StatePublished - Dec 2012

Keywords

  • Biomarker
  • Gene expression
  • Quantitative real-time PCR
  • The amyloid precursor protein-binding protein A2 gene
  • Tourette syndrome

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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