Gender differences in p53 mutational status in small cell lung cancer

Jennifer E. Tseng, Marivonne Rodriguez, Jae Ro, Diane Liu, Waun Ki Hong, Li Mao

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Mutations in the p53 tumor suppressor gene have been demonstrated to be one of the most frequent genetic abnormalities in human cancers. Previous studies have shown that the frequency of p53 mutations is significantly higher in small cell lung cancer than in non-small cell lung cancer. However, this conclusion was based in large part on data derived from tumor cell lines and from studies with relatively small sample sizes and biased gender populations. To determine the mutational frequency in the p53 tumor suppressor gene and a potential difference in gender, we analyzed primary small cell lung cancer tumors from 65 patients (37 males and 28 females) for p53 mutations between exons 5 and 9. Mutations were found in 37 of 65 tumors (57%) within the region of p53 analyzed. Interestingly, none of the tumors from females contained more than one mutation, whereas four of the tumors from males contained more than one mutation. The most common mutation in this population was an adenosine-to-guanine transition (27%), followed by guanine- to-thymidine transversion (17%) and guanine-to-adenosine transition (12%). The gender difference in p53 mutational rate identified in this study suggests that a higher proportion of female tumors may develop through pathways not involving p53 mutations.

Original languageEnglish (US)
Pages (from-to)5666-5670
Number of pages5
JournalCancer research
Volume59
Issue number22
StatePublished - Nov 15 1999

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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