[Gd@c₈₂(OH)₂₂]_n nanoparticles inhibit the migration and adhesion of glioblastoma cells

In our previous study, [Gd@C₈₂(OH)₂₂]_n, a fuller-ene-based nanoparticle, exhibited potent anti-tumor effects in mouse tumor-bearing models without detectable toxicity. The mechanism involved in the anti-tumor effect exerted by [Gd@ C₈₂(OH)₂₂]_n remains to be elucidated. This study found that glioblastoma cells treated with [Gd@C₈₂(OH)₂₂]_n nanoparticles showed a signifcant impairment in migration and adhesion by cell chemotaxis, scratch and adhesion assays in vitro. Furthermore, our data showed that the key proteins, CD40 and ICAM-1, were involved in the inhibition of adhesion in the [Gd@C₈₂(OH)₂₂]_n nanoparticle-treated glioblastoma cells. Thus, our study suggests that the [Gd@C₈₂(OH)₂₂]_n nanopar-ticle is a new potential anti-tumor effector and a therapeutic component for malignant glioblastoma infltration.